نتایج جستجو برای: furin

تعداد نتایج: 1326  

Journal: :The Biochemical journal 1999
A Basak S Cooper A G Roberge U K Banik M Chrétien N G Seidah

Studies were performed to investigate the prohormone/proprotein convertase (PC)-inhibitory properties of chemical constituents of the medicinally active plant Andrographis paniculata (AP; from the family Acanthaceae), also known as 'King of Bitters'. Among the individual components tested against the clinically important convertases, furin and PC1, neoandrographolide (a C3 O-glucoside derivativ...

Journal: :European heart journal 2014
Nicolas Vodovar Marie-France Séronde Said Laribi Etienne Gayat Johan Lassus Riadh Boukef Semir Nouira Philippe Manivet Jane-Lise Samuel Damien Logeart Shiro Ishihara Alain Cohen Solal James L Januzzi A Mark Richards Jean-Marie Launay Alexandre Mebazaa

BACKGROUND Increases in plasma B-type natriuretic peptide (BNP) concentrations in those with acutely decompensated heart failure (ADHF) has been mainly attributed to an increase in NPPB gene transcription. Recently, proBNP glycosylation has emerged as a potential regulatory mechanism in the production of amino-terminal (NT)-proBNP and BNP. The aim of the present study was to investigate proBNP ...

Journal: :The Journal of biological chemistry 1993
A S Galanopoulou G Kent S N Rabbani N G Seidah Y C Patel

Mammalian prosomatostatin (PSS) is cleaved at a dibasic Arg-Lys site to produce somatostatin-14 (SS-14) and at monobasic Arg and Lys sites to yield SS-28 and PSS(1-10) (antrin), respectively. Furin, PC1, and PC2 are three recently discovered mammalian endoproteases localized either to the constitutive (furin) or regulated (PC1, PC2) secretory pathways. In this study we have compared the heterol...

2002
Javier Mercapide Ricardo Lopez De Cicco Daniel E. Bassi Javier S. Castresana Gary Thomas Andres J. P. Klein-Szanto

Purpose: Astrocytoma arises in the central nervous system as a tumor of great lethality, in part because of the invasive potential of the neoplastic cells that are able to release extracellular matrix-degrading enzymes. Furin convertase activates several precursor matrix metalloproteases involved in the breakdown of the extracellular matrix. In the present study inhibition of furin was achieved...

Journal: :The Biochemical journal 2006
Nabil G Seidah

Many viral proteins undergo proteolytic processing events that are required for virus infection and virion assembly. In this issue of Biochemical Journal, Strongin and co-workers report that the NS3 protease from West Nile virus unexpectedly cleaves certain substrates at pairs of basic residues, a specificity that resembles that of the furin-like PCs (proprotein convertases). This led to the de...

2011
Aileen J Zhou Cameron ML Clokie Sean AF Peel

Background Due to their osteoinductive properties, recombinant human bone morphogenetic proteins (rhBMPs) have been used successfully for bone regeneration and replacement. However, the yields rhBMPs yields in mammalian expression systems are very low, resulting in their high cost. BMPs are synthesized as a precursor, proBMP, which undergoes enzymatic cleavage by proprotein convertases (PCs) to...

Journal: :Journal of immunology 2004
Jun Lu Yuichiro Higashimoto Ettore Appella Esteban Celis

We describe in this study a strategy to produce synthetic vaccines based on a single polypeptide capable of eliciting strong immune responses to a combination CTL and Th epitopes with the purpose of treating malignancies or preventing infectious diseases. This strategy is based on the capacity of Trojan Ags to deliver exogenous Ags into the intracellular compartments, where processing into MHC-...

Journal: :PLoS ONE 2009
Katarzyna Gawlik Sergey A. Shiryaev Wenhong Zhu Khatereh Motamedchaboki Roxane Desjardins Robert Day Albert G. Remacle Boguslaw Stec Alex Y. Strongin

BACKGROUND Before furin can act on protein substrates, it must go through an ordered process of activation. Similar to many other proteinases, furin is synthesized as a zymogen (profurin) which becomes active only after the autocatalytic removal of its auto-inhibitory prodomain. We hypothesized that to activate profurin its prodomain had to be removed and, in addition, the emerging enzyme's N-t...

Journal: :Journal of virology 2006
Angela J Sanchez Martin J Vincent Bobbie R Erickson Stuart T Nichol

Crimean-Congo hemorrhagic fever virus (genus Nairovirus, family Bunyaviridae) genome M segment encodes an unusually large (in comparison to members of other genera) polyprotein (1,684 amino acids in length) containing the two major structural glycoproteins, Gn and Gc, that are posttranslationally processed from precursors PreGn and PreGc by SKI-1 and SKI-1-like proteases, respectively. The char...

Journal: :Journal of Biological Chemistry 2000

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید