1例目は71歳，女性．動悸を主訴に当科を紹介受診した．血色素7.7 g/dl，ハプトグロビン10 mg/dl以下，Coombs試験陽性から自己免疫性溶血性貧血（AIHA）と診断された．プレドニゾロン（prednisolone，PSL）投与が著効したが，AIHAの診断後1年8カ月経過した頃よりALP，γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し，肝組織検査で中沼分類stage 2の原発性胆汁性胆管炎（PBC）と診断された．2例目は67歳，男性．褐色尿を主訴に当科を紹介受診した．血色素が10.3 g/dl，ハプトグロビンが10 mg/dl以下，Coombs試験が陽性であり，AIHAと診断された．1例目同様にPSLが著効したが，初診時からの持続的なALP，γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し，肝組織検査で中沼分類stage 2のPBCと診断された．2症例...

We report a case of multiple autoimmunity consisting of the presence of autoimmune haemolytic anaemia (AIHA), antimitochondrial antibodies (AMAs), and antiphospholipid antibodies (APLAbs) as the presenting manifestations of an extrahepatic B-non-Hodgkin lymphoma (B-NHL) in a 63-year-old woman. The patient presented with fatigue attributed to severe AIHA. Due to increased serum IgM and γ-GT leve...

Bone marrow transplantation is an emerging tool for treatment of immune-mediated diseases. The use of animal models have shown that these diseases can be treated by hematopoietic stem cell transplantation. These findings have recently been confirmed in humans; diseases like multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus were resolved or alleviated after allogeneic or ...

Introduction: To present the clinical findings of Autoimmune hemolytic anemia (AIHA) Retinopathy and its rapid resolutions following treatment with steroid. 
 Case report: A 14-year-old female patient presented decreased vision in left eye. There was history AIHA. Visual acuity 1/60 LE 6/6 RE. conjunctival pallor, other anterior segment were unremarkable. Fundus examination eye revealed fl...

Evans syndrome (ES) is a rare disease characterized by the simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) and/or immune neutropenia. To better describe the characteristics and outcome of ES in adults, a survey was initiated in 2005. The data from 68 patients (60% of them women) fulfilling strict inclusion criteria for ES are report...

BACKGROUND Autoimmune haemolytic anaemia (AIHA) is a rare complication following kidney transplantation and usually occurs early in its course. It is characterised by autoantibodies or alloantibodies directed against red blood cells (RBCs). CASE PRESENTATION We describe a 44 year old woman who presented 5 years after kidney transplantation with profound transfusion dependent warm AIHA. Invest...

By ROBERT SCHWARTZ AND WILLIAM DAMESHEK P RIOR TO 1949, the treatment of autoimmune hemolytic anemia ( AIHA) was frequently disappointing. Despite splenectomy and the use of blood transfusions, many patients had an unremitting and progressively deteriorating course which ended fatally. With the introduction of ACTH and cortisone, the treatment of this disorder was greatly facilitated and benefi...

This study was performed to determine whether there is any distinction to be made between single and multiple-lineage cytopenias particularly with regard to natural history and prognosis. From December 1989 to May 1994, five of 50 children (median age 7 years) with chronic immune cytopenias were diagnosed with multi-lineage immune- ediated cytopenias. Two patients presented with immune thromboc...

Conventional pretransfusion testing based on hemagglutination assays can be challenging for patients with autoimmune hemolytic anemia (AIHA) because of the presence of auto-antibodies. It has been suggested that deoxyribonucleic acid-based methods could be more efficient in the selection of antigen-matched red blood cell units in those settings. Because of the high risk of alloimmunization of t...

In anti-red blood cell autoantibody transgenic (autoAb Tg) mice almost all B cells are deleted except for B-1 cells in the peritoneal cavity and the gut. About one-half of the auto Ab Tg mice suffer from autoimmune hemolytic anemia (AIHA) in the conventional condition. Oral administration of lipopolysaccharides activates B-1 cells and induces autoimmune symptoms in the Tg mice, suggesting that ...