A 67 year old female presented with generalized weakness, falls and recurrent high grade fevers for 5 6 weeks. Physical findings included high grade temperature, lower extremity weakness and diminished reflexes. An extensive work-up for fever of unknown origin (FUO), including PET-FDG scan, did not yield any occult infectious or neoplastic process. Ultimately a temporal artery biopsy was planne...

We report on an 83-year-old Japanese woman with adult-onset Still's disease (AOSD), with marked hypercytokinemia (serum levels of ferritin (Fer) and interleukin (IL)-18 were markedly high). On seeing older patients with fever of unknown origin (FUO), particularly Asians, AOSD should be considered. Reduced doses of oral prednisolone following intravenous methylprednisolone (mPSL) therapy caused ...

n engl j med 368;3 nejm.org january 17, 2013o 197 as they define it — a tempera­ ture rising above 38.3°C (101°F) on several occasions over a peri­ od of more than 3 weeks, for which no diagnosis has been reached despite 1 week of inpa­ tient investigation — is con­ sidered classic FUO. In the past 60 years, clinician­scientists have tracked the changing causes of these problematic fevers, as d...

This study involved 115 cases of fever of unknown origin (FUO) patients who were admitted to the Department of Medicine, Siriraj Hospital from May 1999 to November 2000. Among the patient sera screened by ELISA for IgG Hantavirus, five were positive for IgG Hantavirus-reacting antibodies and eight tested positive for IgM Hantavirus-reacting antibodies. One serum had both IgG and IgM antibodies....

This prospective study was done to assess the frequency of acute pyelonephritis (APN) in febrile children with positive urine culture as documented by Tc99m DMSA scintigraphy (DMSA) and the frequency of vesicoureteric reflux (VUR) in these children. Secondly, to determine the frequency of APN, in febrile children with supportive evidence for UTI but with negative urine culture, as documented by...

Patients with cancer of unknown primary site are common, representing 5%10% of all cancer patients (7). Combination chemotherapy, often used with surgery or radiation therapy, has proved to be potentially curative for several metastatic tumors of known primary site. Likewise, some patients with metastasis of unknown origin (MUO) also have responsive neoplasms and could be treated successfully (...