INTRODUCTION Constipation is a common complaint in children and early intervention with oral laxatives may improve complete resolution of functional constipation. However, most treatment guidelines are based on reviews of the literature that do not incorporate a quality assessment of the studies. OBJECTIVE To investigate and summarise the quantity and quality of the current evidence for the e...

Introduction ..................................................... 1 Functional Constipation .................................. 2 Opioid-Induced Constipation........................... 2 Prevalence .................................................. 3 Role of Opioid Receptors............................ 3 Differential Opioid Effects ........................... 3 Patient Assessment & Treatment......

Functional constipation is one of the most common gastrointestinal symptoms across the globe. Its high prevalence rate, economic burden, and adverse implications on the quality of life make constipation a major public health issue. Though various treatment options are available for the management of constipation, evidence for their efficacy and safety are limited. An open-label, prospective, in...

1. Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran 2. Dept. of Ophthalmology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 3. Gastroenterology Section, Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 4. Dept. of Pharmacognosy, School of Pharmacy, S...

Functional constipation (FC) is a common and often recurrent functional bowel disorder that seriously affects the quality of life affected individuals incurs significant economic burden on both individual society. There accumulating evidence intestinal dysbiosis contributes to rebalancing gut microbiota may be novel therapeutic modality for FC. Electroacupuncture (EA) has been shown restore nor...

Chronic functional constipation is common in infants, and the bacterial composition of stools in this condition is not known. The study aims were to: (i) investigate the composition of the intestinal ecosystem in chronic functional constipation; (ii) establish whether the addition of the water-holding agent calcium polycarbophil to the diet induces an improvement in constipation; and (iii) dete...