نتایج جستجو برای: fulvestrant

تعداد نتایج: 782  

2006
Barbara Kuske Catherine Naughton Kate Moore Kenneth G MacLeod William R Miller Robert Clarke Simon P Langdon David A Cameron

Hormone-dependent estrogen receptor (ER)-positive breast cancer cells may adapt to low estrogen environments such as produced by aromatase inhibitors. In many instances, cells become insensitive to the effects of estrogen but may still retain dependence on ER. We have investigated the expression, function, and activation of ERa in two endocrine-resistant MCF-7 models to identify mechanisms that...

2013
Tissa T. Manavalan Yun Teng Lacey M. Litchfield Penn Muluhngwi Numan Al-Rayyan Carolyn M. Klinge

INTRODUCTION The role of miRNAs in acquired endocrine-resistant breast cancer is not fully understood. One hallmark of tumor progression is epithelial-to-mesenchymal transition (EMT), characterized by a loss of cell adhesion resulting from reduced E-cadherin and increased cell mobility. miR-200 family members regulate EMT by suppressing expression of transcriptional repressors ZEB1/2. Previousl...

2009
Joan Manel Gasent Blesa Vicente Alberola Candel

Metastatic prostate cancer is an incurable disease. After a period of hormone sensitivity that allows for the use of antiandrogens, the disease invariably progresses to a situation of androgen-independent growth, which deserves the consideration or the use of chemotherapy. As many of these patients are elderly and fragile, treatment with chemotherapy is challenging. Therefore, new drugs are req...

Journal: :Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2016
Maki Nakai Hiroyuki Takei Keiko Yanagihara Koji Yamashita Eiji Uchida

Although the use of endocrine therapy in combination with intravenous chemotherapy has not been standardized, the combination of fulvestrant and chemotherapy may be promising. A 62-year-old woman came to our hospital's outpatient clinic with extensive ascites. Approximately 10 years earlier, she had undergone mastectomy and sentinel lymph node biopsy. Pathologically invasive lobular carcinoma, ...

Journal: :ESMO open 2023

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are usually combined with fulvestrant or aromatase for the treatment of patients metastatic breast cancer (mBC). Drug-drug interactions may affect absorption by different mechanims, instance, modification digestive pH. Proton pump (PPIs) known to reduce oral bioavailability some anticancer drugs. Palbociclib is a weak base pH-dependent solubil...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Peter F Bross Amy Baird Gang Chen Josephine M Jee Richard T Lostritto David E Morse Liliam A Rosario Gene M Williams Peiling Yang Atiqur Rahman Grant Williams Richard Pazdur

PURPOSE Patients with hormone-sensitive breast cancer who have responded to tamoxifen (TAM) may receive additional benefit from a second endocrine agent after progression or relapse after TAM therapy. Fulvestrant (FVT; Faslodex; i.m. injection, ICI 182,780; AstraZeneca Pharmaceuticals, Wilmington, DE) was developed as a selective antagonist of estrogen. In postmenopausal women, FVT is reported ...

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