This study aimed to investigate the ability of an autologous cultured composite skin (CCS) to close similar biodegradable temporizing matrix (BTM)-integrated wounds, and its effectiveness in healing fresh full-thickness wounds after the failure of cultured epithelial autograft in its two forms (sheets and suspensions) to epithelialize over an integrated polymer BTM. Using a porcine model, autol...

background: teat lacerations are serious injuries thatendanger the survival of a cow within the herd. in excessivelacerations, the wound should be left to heal by second intentionhealing process. however, tissue contraction during healing canchange the alignment of the teat, creating problems for machinemilking. objectives: the purpose of the present study was toevaluate the transplantation of ...

AIM There are few complications associated with harvesting of full thickness coastal cartilage grafts i.e., pneumothorax (0.9%), contour deformities and prolonged post-operative pain. To address these issues, authors devised special scalpel to harvest split-thickness costal cartilage grafts. MATERIALS AND METHODS Standard inframammary incision was used for harvesting rib. Incision was made di...

Oral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming hypertrophic scars. Differences in wound healing and final scar quality might be related to differences in mesenchymal stromal cells (MSC) and their ability to respond to intrinsic (autocrine) and extrinsic signals, such as human salivary histat...

In a series of experiments full thickness skin defects in 68 rats were covered with dressings made of boiled potato peels according to the method developed in Bombay. The wounds closed within 14 days and histologically complete repair of epidermis was found. The cork layer of the potato peel prevents dehydration of the wound and protects against exogenous agents. Experiments with homogenates re...

It is well-understood that wound care poses a significant burden on the healthcare system and patient well-being. As such, it imperative to develop efficient methods facilitate tissue repair. Our group previously developed nutritional gel scaffold, proven accelerate Due its gel-like properties, this scaffold requires time-consuming reconstitution, optimized for cavernous wounds. This pilot stud...

Electrolyzed water accelerated the healing of full-thickness cutaneous wounds in rats, but only anode chamber water (acid pH or neutralized) was effective. Hypochlorous acid (HOCl), also produced by electrolysis, was ineffective, suggesting that these types of electrolyzed water enhance wound healing by a mechanism unrelated to the well-known antibacterial action of HOCl. One possibility is tha...

Third-degree burn wounds can cause devastating loss of functionality for patients. As such, platform technologies that allow effective wound management are needed. The purpose this study is to describe the use MatriStem™ urinary bladder matrix (UBM)-based products (MicroMatrix® + Cytal®) (MM+C) and a collagen glycosaminoglycan (GAG) product (Integra® Dermal Regeneration Template (DRT)) (DRT) in...

Cultured skin substitutes have become useful as adjunctive treatments for excised, full-thickness burns, but no skin substitutes have the anatomy and physiology of native skin. Hypothetically, deficiencies of structure and function may result, in part, from nutritional deficiencies in culture media. To address this hypothesis, vitamin C was titrated at 0.0, 0.01, 0.1, and 1.0 mM in a cultured s...