Title: Fucoidan present in brown algae induces apoptosis of HT-29 human colon cancer cells

We investigated the effect of fucoidan, a sulfated polysaccharide, on acceleration of healing of experimental cartilage injury in a rabbit model. An injured cartilage model was surgically created by introduction of three holes, one in the articular cartilage of the medial trochlea and two in the trochlear sulcus of the distal femur. Rabbits in three experimental groups (F groups) were orally ad...

In this study, we showed that PI3K/Akt signaling mediates fucoidan's anticancer effects on prostate cancer cells, including suppression of proliferation. Fucoidan significantly decreased viability of DU-145 cancer cells in a concentration-dependent manner as shown by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. The drug also significantly increased chromatin condens...

Sulphated polysaccharides (SP) extracted from seaweeds have antiviral properties and are much less cytotoxic than conventional drugs, but little is known about their mode of action. Combination antiviral chemotherapy may offer advantages over single agent therapy, increasing efficiency, potency and delaying the emergence of resistant virus. The paramyxoviridae family includes pathogens causing ...

Gastric ulcers and related complications associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, represent a major global health problem. In the present study, we investigate the immunological activity of fucoidan against aspirin-induced gastric mucosal damage in rats. Thirty-six rats were randomly divided into the following, normal (Carboxy methyl cellulose ...

Macrophage death in advanced atherosclerosis promotes plaque necrosis and destabilization. Involvement of autophagy in bulk degradation of cellular components has been recognized recently as an important mechanism for cell survival under endoplasmic reticulum (ER) stress. We previously found that the engagement of class A scavenger receptor (SR-A) triggered JNK-dependent apoptosis in ER-stresse...

Supplementary Fig. S2 Rotem analysis. (A) Representative human whole blood thromboelastogram (ROTEM) profiles. Venous blood was preincubated with a sub-threshold recombinant tissue plasminogen activator (rtPA) alone (1.1 nmol/L), rtPA/DLF (1.1 nmol/L), NF alone, DLF alone and rpTF/NF. (B) In each condition, the rate of fibrinolysis was assessed by the reduction of the amplitude of the thromboel...

Fucoidans are widespread cost-effective sulfated marine polysaccharides which have raised interest in the scientific community over last decades for their wide spectrum of bioactivities. Unsurprisingly, nanomedicine has grasped these compounds to develop innovative therapeutic and diagnostic nanosystems. The applications of fucoidans in nanomedicine as imaging agents, drug carriers or for their...

HfO 2 NPs surface functionalized with fucoidan show specific targeting of aggregated platelets and appear as a new candidate for X-ray imaging the molecular-scale diagnosis atherothrombosis.

Abstract Stabilization of nano-oxide suspensions is a very important process. Nowadays, synthetic polymers are used to increase stability the colloidal systems. However, this solution not ecological and incompatible with principles green chemistry. Instead polymers, their natural counterparts can be used. Herein, we present use bioactive polysaccharide—fucoidan as stabilizer nano-zinc(II) nano-...