Mammalian studies show that frustration is experienced when goal-directed activity is blocked. Despite frustration's strongly negative role in health, aggression and social relationships, the neural mechanisms are not well understood. To address this we developed a task in which participants were blocked from obtaining a reward, an established method of producing frustration. Levels of experien...

Population-scale sequencing is increasingly uncovering large numbers of rare single-nucleotide variants (SNVs) in coding regions of the genome. The rarity of these variants makes it challenging to evaluate their deleteriousness with conventional phenotype-genotype associations. Protein structures provide a way of addressing this challenge. Previous efforts have focused on globally quantifying t...

BACKGROUND Students of health-professions suffer high levels of stress and burnout. The aim of the present study was to evaluate the relationship between perceived stress latent factors ('tenseness' and 'frustration') and the features ('overload', 'lack of development' and 'neglect') of the three burnout subtypes ('frenetic', 'under-challenged' and 'worn-out', respectively), in a sample of Span...

Magnetic ground states in solids often arise as a result of a delicate balance between competing factors. One currently active area of research in magnetic materials involves compounds in which long-range magnetic ordering at low temperatures is frustrated by the geometry of the crystalline lattice, a situation known as geometrical magnetic frustration. The number of systems known to display th...

any reasonable person concludes a contract in order to attain (a) purpose(s). it sometimes arises that unforeseen occurrences, subsequent to the date of the contract, make worthless the promisee’s counter-performance for promisor without it has been become physically impossible or impracticability. this situation is analyzed under the doctrine of “frustration of purpose” in american law. nevert...

We present a quantitative asymptotic behavior of coupled Kuramoto oscillators with frustrations and give some sufficient conditions for the parameters and initial condition leading to phase or frequency synchronization. We consider three ensembles of Kuramoto oscillators with frustration. First, we study a general case with nonidentical oscillators; i.e., the natural frequencies are distributed...

Frustration is almost universally accepted as the emotional outcome of a negative computing experience. Despite the wide use of the term, however, it has not been rigorously conceptualized as a factor in the study of the human–computer interface. This project sets out to explicate frustration as a pre-emotional state generated by the user’s appraisal of the interface as an impediment to goal at...

Idealized nanowire geometries assume stable sidewalls at right angles to the growth front. Here we report growth simulations that include a mix of nonorthogonal facet orientations, as for Au-catalyzed Si. We compare these with in situ microscopy observations, finding striking correspondences. In both experiments and simulations, there are distinct growth modes that accommodate the lack of right...

Covering a graph or a lattice with nonoverlapping dimers is a problem that has received considerable interest in areas, such as discrete mathematics, statistical physics, chemistry, and materials science. Yet, the problem of percolation on dimer-covered lattices has received little attention. In particular, percolation on lattices that are fully covered by nonoverlapping dimers has not evidentl...

Although abundant research has shown that self-critical perfectionism relates to binge eating symptoms, fewer studies have addressed the role of intervening processes that might explain why this is the case. Grounded in Self-Determination Theory, we hypothesized that selfcritical perfectionism would relate to an increased risk for binge eating symptoms because it engenders frustration of the ps...