Microtubules can adjust their length by the mechanism of dynamic instability, that is by switching between phases of growth and shrinkage. Thus far this phenomenon has been studied with microtubules that contain several components, that is, a mixture of tubulin isoforms, with or without a mixture of microtubule-associated proteins (MAPs), which can act as regulators of dynamic instability. Here...

The construction of various of Klein bottles that belong to different regular homotopy classes, and which thus cannot be smoothly transformed into one another, is formally introduced. For all cases it is shown how these shapes can be partitioned into two Moebius bands and how the twistedness of these bands defines the homotopy type. Some wild and artistic variants of Klein bottles are presented...

CD27 is an important co-stimulatory receptor of T cells that can potentially be exploited for immunotherapy. We developed a human IgG1 antibody that targets human CD27, and demonstrated its immunostimulatory and antineoplastic activity in various preclinical models. Currently, the antibody (1F5, CDX-1127) is being tested in patients affected by advanced malignancies.

http://dx.doi.org/10.1016/j.foreco.2015.03.052 0378-1127/ 2015 Elsevier B.V. All rights reserved. ⇑ Corresponding author. E-mail addresses: [email protected] (F. Vodde), [email protected] (K. Jõgiste), [email protected] (J. Engelhart), [email protected] (L.E. Frelich), [email protected] (W.K. Moser), [email protected] (A. Sims), [email protected] (M. Metslaid). Floor Vodde a,⇑,...

In order to study the genetic diversity in rice (Oryza sativa L.), 29 genotypes consisting land races, pure and improved lines were evaluated using simple sequence repeat (SSR) markers. A total of 30 SSR primers were used to amplify some part of rice genome in germplasms, the PIC values ranged from 0.07 (RM 340) to 0.71 (RM 7426) with an average of 0.45. The results showed a total number of 106...

in the present study, randomly amplified polymorphic dna (rapd) markers were used to analyze the genetic diversity in 20 varieties of philodendron. the polymerase chain reaction was performed with 60 rapd primers, out of which 21 primers showed clear amplification as well as more polymorphism. in total, 354 scorable rapd loci with 348 polymorphic bands (98%) were observed. percentages of polymo...