In contrast to the dozens of proteins involved in ubiquitination pathways, relatively few proteins control SUMO modification. Generating specificity and diversity in pathway outcomes may therefore rely on post-translational modification of pathway components and/or substrates. A new paper in The EMBO Journal identifies one such modification event, the acetylation of Ubc9, as a key regulatory st...

Given any positive integer $n,$ let $A(n)$ denote the height of $n^{\text{th}}$ cyclotomic polynomial, that is its maximum coefficient in absolute value. It well known unbounded. We conjecture every natural number can arise as value and prove this assuming for pair consecutive primes $p$ $p'$ with $p\ge 127$ we have $p'-p<\sqrt{p}+1.$ also occurs some polynomial show true if Andrica's always $\...

Shock tubes have been extensively used in the study of blast traumatic brain injury due to increased incidence of blast-induced neurotrauma in Iraq and Afghanistan conflicts. One of the important aspects in these studies is how to best replicate the field conditions in the laboratory which relies on reproducing blast wave profiles. Evolution of the blast wave profiles along the length of the co...

A group of order n is said to be R-sequenceable if the nonidentity elements of the group can be listed in a sequence a,, a,, . . . , a,_ 1 such that the quotients a; ‘az, a; ’ a3, . , a;?,a,_ r, a.-_‘,a, are distinct. An abelian group is R*-sequenceable if it has an R-sequencing a,, a,, . . , a,, _ 1 such that a,_ ra, + r = ai for some i (subscripts are read modulo n 1). Friedlander, Gordon and...

Quinolines are a prominent heterocyclic motif and crucial building blocks in creating physiologically active compounds. Due to the fast development of novel medicines with quinoline nucleus, numerous research papers have been published short amount time. Therefore, comprehend present state nucleus medicinal chemistry science, it is necessary combine new information older data. So far, several t...