Perforated peptic ulcer disease remains a relatively frequent emergency surgery presentation. Persistent leak is the most common indication for return to theatre. We present a technique to manage patients in whom a more substantial resection is not possible. A 45-year-old woman underwent initial laparoscopic primary closure of a non-malignant perforated gastric ulcer. This subsequently leaked o...

The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for ph...

SUMMARY The resection of neurofibromas in Von Recklinghausen's disease [neurofibromatosis type 1 (NF-1)] is frequently complicated due to size, location, hypervascularity, and tissue friability. A repeat resection, however, is necessary for patients with functional problems such as unexpected tumor bleeding or with changes in esthetic appearance. This report describes application of the method ...

The Ehlers-Danlos syndrome is an uncommon hereditary disorder of connective tissue. The main characteristics are joint hypermobility and skin hyperextensibility. Easy bruising, poor healing with wide gaping scars, and cardiovascular, gastrointestinal , orthopedic , and occular manifestations may also occur. The syndrome is considered heterogeneous [1] and different variants of the syndrome have...

An 11-year-old, neutered, male French bulldog was referred for surgical repair of an incidentally diagnosed pleuroperitoneal diaphragmatic hernia. Thoracic computed tomography revealed a left centroventral hernia with large volume left-sided intrathoracic fat. A minimally invasive laparoscopic approach elected. portion the fat laparoscopically reduced. Adhesions and friability herniated prevent...

Orally disintegrating tablets (ODTs) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. The aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...

From the first liver resection by A. Luis in 1886 to modern day liver transplantation, hepatobiliary surgery has witnessed major advancements over the last century. Much of this technical achievement has been attained on the back of progressively improved understanding of the liver anatomy and its potential variant. From Cantlie to Couinaud, many anatomists contributed towards this modern-day u...

Stavudine oral disintegration tablets were formulated to minimize the bitter taste and to reduce the first-pass hepatic metabolism. The various precompression parameters like the angle of repose, bulk density, compressibility index and Hausner's ratio were determined for the powder blend. In this study, 14 formulations of stavudine oral disintegration tablet were prepared by direct compression ...

The objectives of present investigation were to achieve immediate release of paracetamol and tailored release of diclofenac sodium from bi-layer tablets. A 2(3) full factorial design was adopted using the amount of polyethylene glycol, microcrystalline cellulose and crospovidone as independent variables for fabricating paracetamol tablets. Diclofenac sodium tablets were prepared using hydroxypr...

Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches. Various pellet properties were evaluated like size & shape analysis, flow properties, bulk & tapped density, friabilit...