Cicer Arietinum (Leguminosae) is an annual herb, known as local Indian name ‘Kala Chana’. Its root was extracted using solvents of different polarities and explored for invitro free radical scavenging activity. Preliminary assays of three different extracts of Cicer Arietinum root, scavenges 1, 1-diphenyl-2-picrylhydrazyl stable free radicals in concentration dependent manner. All studied extra...

The flower pigment of Calliandria suninamensis is used folklorically as a colorant and a dye. The crude powdered sample and methanolic extract of the plant were subjected to phytochemical, proximate analysis and antioxidant activities. Parameters like moisture content, ash values and extractive values were determined. The methanolic extract was evaluated for its antioxidant/free radical scaveng...

The p53 tumor suppressor is a transcription factor that regulates several pathways, which function collectively to maintain the integrity of the genome. Nuclear localization is critical for wild-type function. However, the signals that regulate subcellular localization of p53 have not been identified. Here, we examine the effect of ionizing radiation on the subcellular localization of p53 in tw...

The focus of this review is to provide state-of-the-art knowledge on the involvement of oxygen free radicals (OFR) in carcinogenesis with a particular reference to skin model system as the process of cancer development is best understood in this organ. However, a brief description of the role of OFR in other organs is also provided. The term OFR refers to forms of oxygen exhibiting high reactiv...

The methanol extract of the dried ripe fruits of Alpinia rafflesiana was investigated for its DPPH free radical scavenger constituents. 2',3',4',6'-Tetrahydroxychalcone (7), which has never been isolated from natural sources was found to be most active as a DPPH free radical scavenger with the IC50 value of 55 microM. Other known compounds isolated from this species include 5,6-dehydrokawain (1...

Oxygen-derived free radical formation can lead to cellular injury and death. Under normal situations, the human body has a free radical scavenger system (catalase, superoxide dismutase) that can detoxify free radicals. Antioxidant vitamins and enzymatic and synthetic oxygen-derived free radical scavengers have been used clinically to prevent the formation of oxidized LDL and to prevent reperfus...

One concern in using photonic band-gap fiber (PBGF) as a gas sensor is the response time. In this type of the gas sensors, response time is the time required for gas to diffuse into the hollow-core. So considering a large hollow-core PBGF (HC-PBGF), the response time can be significantly reduced. But in the large HC-PBGF, the fundamental issue is the presence of higher order modes (HOMs). Somet...