Background and objectives: Ferula gummosa Boiss. (Umbelliferae) is a popular medicinal plant, which is known mostly for therapeutic uses of its oleo-gum-resin (Barijeh in Persian). In the present study, the essential oil of F. gummosa roots was investigated for its phytochemical constituents, antioxidant activity and toxicity potential. Method...

Although it is known that accumulation of oncogenic β-catenin is critical for intestinal tumorigenesis, the underlying mechanisms have not yet been fully explored. Post-translational β-catenin level is regulated via the adenomatous polyposis coli (APC)-dependent as well as the APC-independent ubiquitin-proteasome pathway (UPP). Employing an APC-mutant mouse model (APC(Min/+)) the present study ...

salvia genus is one of the largest genera of the lamiaceae family. its species have been used for a wide variety of disorders in the local traditional medicine systems. therefore, the genus has been the subject of several phytochemical and biological studies. the aim of the study was to identify the major antioxidant compound(s) from the methanol extract of salvia verticillata using activity-gu...

We consider the influence of a shifting environment and an advection on the spreading of an invasive species through a model given by the diffusive logistic equation with a free boundary. When the environment is shifting and without advection (β = 0), Du, Wei and Zhou in [16] showed that the species always dies out when the shifting speed c∗ ≥ C, and the long-time behavior of the species is det...

We examined the influence of caffeine on the proliferation and apoptosis of β cells cultured in vitro in the presence of the free fatty acid palmitic acid (PA). Different concentrations of caffeine (1-100 mM) and free fatty PA were added to cultured β cells. The MTT assay was used to analyze cell proliferative activity; flow cytometry was used to measure apoptosis and calculate the apoptosis ra...

The aim of this in vivo study was to assess the ability of the prodrug conjugate diclofenac-β-cyclodextrin to release diclofenac in the colon following oral administration, using sulfapyridine (a metabolite of sulfasalazine) as a marker of colonic absorption. Two groups of rats were used; the test rats received a suspension containing the two prodrugs, diclofenac-β-cyclodextrin and sulfasalazin...

An overlap is a word of the form axaxa, where a is a single letter and x is a (possibly empty) word. In 1980, Earl Fife [8] proved a theorem characterizing the infinite binary overlap-free words as encodings of paths in a finite automaton. Berstel [4] later simplified the exposition, and both Carpi [6] and Cassaigne [7] gave an analogous analysis for the case of finite words. In a previous pape...

OBJECTIVE It was the aim of this study to examine the possible effects of maternal and fetal characteristics on the fetal fraction in maternal plasma cell-free DNA (cfDNA) at 11-13 weeks' gestation. METHODS In a nested case-control study, cfDNA was extracted from maternal plasma obtained before chorionic villous sampling from 300 euploid, 50 trisomy 21 and 50 trisomy 18 pregnancies at 11-13 w...

OBJECTIVE To estimate the difference between levels of the two biochemical markers pregnancy-associated plasma protein-A (PAPP-A) and maternal serum free β-human chorionic gonadotropin (free β-hCG) in twin pregnancies relative to singleton pregnancies and establish an improved screening procedure for chromosomal abnormalities such as trisomy 21 in twin pregnancies. METHODS 4843 unaffected and...

Epithelial-mesenchymal crosstalk is vital for balancing expansion and regression of the progenitor cell pool during tissue turnover. In hair growth cycle, little known about mechanisms underlying regulated death follicle that precedes each regeneration re-growth. Here, we discover dermal sheath smooth muscle, which lines all follicles, controls via transforming factor (TGF)-β mechanosignaling. ...