Introduction Lentigo Maligna (LM) typically presents at sun-exposed sites in elderly patients as an asymmetric, slow-growing, irregularly pigmented macule with an irregular indented border. With changes in sun exposure behaviour LM is becoming more prevalent in middle-aged and younger adults.1 The risk of melanoma developing in LM increases with duration of the disease and therefore age,2 and i...

Mechanisms involved in melanoma invasiveness and metastasis are essential to understanding the behavior of this aggressive melanocytic skin cancer. The epithelial-mesenchymal transition (EMT) is considered fundamental for overcoming the in situ stage of melanoma and its proliferation beyond the basal membrane. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are key molecule...

A solar lentigo is a flat, sharply circumscribed patch. It can be round, oval or irregular in shape. Color varies from skincolored, brown to dark brown or black, and size varies from a few millimeters to several centimeters in diameter [1, 2]. It results from long-term exposure to Ultraviolet (UV) radiation, which causes local proliferation of epidermal melanocytes and accumulation of melanin w...

Patient 1 is a 70-year-old woman that presented with a biopsy-proven lesion of Bowen’s disease [squamous cell carcinoma (SCC) in situ] on the left arm. She was 17 years status postrenal transplantation for which she was taking imuran and prednisone. She recently had a lentigo maligna excised from her cheek. Physical examination revealed a 3 cm 3 cm mildly hyperkeratotic pink/red plaque on the l...

Cutaneous malignant melanomas with histologic evidence of an associated nevus (N+) may have a different risk factor profile from that of melanomas without it (N-). To address this question, a case-only analysis of 932 people with cutaneous malignant melanoma was done to identify etiologic and other factors associated with N+ melanoma. Evidence of an associated nevus was found in 36% of melanoma...

BACKGROUND The incidence of melanoma has been steadily rising in past decades. Although it accounts for only 3% of all skin cancers, it is responsible for 75% of deaths. OBJECTIVE to describe the epidemiological aspects of melanoma in a university hospital setting over a period of 20 years. METHODS A total of 166 patients were analyzed between January 1990 and January 2010 for clinical and ...

1. Gage AA, Meenaghan MA, Natiella JR, Green GW Jr. Sensitivity of pigmented mucosa and skin to freezing injury. Cryobiology 1979; 16: 348 ± 361. 2. Zouboulis ChC. Principles of cutaneous cryosurgery: an update. Dermatology 1999; 198: 111 ± 117. 3. Almond-Roesler B, Zouboulis ChC. Milde Kryochirurgie zur Behandlung aktinischer Lentigines. Allergologie 1999; 21: 420 ± 421. 4. Stern RS, Dover JS,...

Cutaneous malignant melanoma (CMM) is currently the most fatal of skin cancers accounting for 50000 deaths annually. Five distinct melanomas are described histopathologically: superficial spreading, lentigo maligna, nodular, acral lentiginous and mucosal melanoma. The aim of this study was to investigate the characteristics of patients with various types of malignant melanoma and evaluate histo...

Solar lentigo (SL) is a representative photoaging skin disorder. Alteration of the main epidermal constituent cells-keratinocytes and melanocytes-in relation to the photoaged dermal environment or chemokine/cytokine network is suggested as its pathogenesis. Among these, we focused on monocyte chemoattractant protein-1 (MCP-1), as it is known to be associated with tissue aging. For the first tim...

The aim of the present population-based descriptive study was to evaluate the incidence and mortality trends for melanoma to gain insights on the effectiveness of opportunistic secondary prevention strategies. Data on all invasive cutaneous melanoma cases occurring between 1996 and 2011 were retrieved from the Ticino Cancer Registry, southern Switzerland. The European age-standardized incidence...