This paper describes the application of an Intelligent Genetic Design Tool (IGDT) in the design of architectural, structural elements. As a computer design aid an IGDT is innovative in its intelligent interaction with the designer. By always submitting multiple solutions for review by the designer, it is less likely to cause design fixation than other optimization techniques, and allows the use...

TOPIC: Obstructive Lung Diseases TYPE: Original Investigations PURPOSE: In 2018, 16.4 million U.S. adults reported a diagnosis of Chronic Pulmonary Disease (COPD) with annual healthcare costs projected to reach $49 billion by 2020. Up 70% COPD-related expenditures are attributable acute COPD exacerbations. The 2018 Global Initiative for (GOLD) recommends long-acting muscarinic antagonists/beta2...

The styles of continuing intellectual traditions can have a major effect on the way in which scientific findings are expressed. Darwin and Huxley, for all their intellectual daring followed the skeptical tactics of the Scottish Enlightenment and avoided the construction of human phylogenetic trees, even though they were aware of the evidence on which such could have been constructed. The romant...

THE American Dairy Science Association was organized as the National Association of Dairy Instructors and Investigators on 17 July 1906 at the University of Illinois. The proceedings and program of this meeting were published as an Illinois Experiment Station circular in 1907. W. J. Frazer, University of Illinois, was one of the early leaders in the development of the association. The meetings ...

We present full-genome genotype imputations for 100 classical laboratory mouse strains, using a novel method. Using genotypes at 549,683 SNP loci obtained with the Mouse Diversity Array, we partitioned the genome of 100 mouse strains into 40,647 intervals that exhibit no evidence of historical recombination. For each of these intervals we inferred a local phylogenetic tree. We combined these da...

C linical & Translational Immunology (CTI) has been launched as the sister journal to Immunology and Cell Biology (ICB), with the goal of creating an open-access publication focused on quality clinical research and reports that would be immediately and freely available to all interested readers. ICB has a long and illustrious history, being founded in 1924 as the Australian Journal of Experimen...

In this study, [1251]iodocyanopindolol ([125I]ICYP), in the presence of isoproterenol, was used to label 5-hydroxytryptaminelB (5HTIB) receptors in homogenates of the cortex, substantia nigra and caudate-putamen of the rat. The determination of the appropnate concentrations of isoproterenol required to block optimally beta adrenoceptors whereas producing minimal occupancy of 5HT1B receptors was...

By comparing records of the radial component of motion of teleseismic P waves to records of the vertical component, it is possible to identify S phases within the P wave form. These phases are generated by the mechanism of P to S conversion at discontinuities in velocity under the receiving station. Similar phases of the S to P converted type appear as precursors to the direct SV arrival. Model...

—Splittail Pogonichthys macrolepidotus is a relatively large cyprinid endemic to the San Francisco Estuary watershed. During late winter and early spring, splittails migrate from the estuary to upstream rivers and floodplains for spawning. During 2002 and 2003, we examined the diet composition, muscle stable isotope signatures (dC and dN), and growth rates of age-0 splittails in the four primar...