The chemokine CX3CL1 promotes trafficking of dendritic cells through 1 inflamed lymphatics 2 Louise A. Johnson and David G. Jackson 3 Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular 4 Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK 5 Correspondence to: Louise A. Johnson; email: [email protected] 6 Running Title: CX3CL1-dependent lym...

Chronic pain is a distressing condition, which is experienced even when the painful stimulus, whether surgery or disease related, has subsided. Current treatments for chronic pain show limited efficacy and come with a host of undesirable side-effects, and thus there is a need for new, more effective therapies to be developed. The mechanisms underlying chronic pain are not fully understood at pr...

Chronic pain represents a major problem in clinical medicine. Whilst the acute pain that is associated with tissue injury is a protective signal that serves to maintain homeostasis, chronic pain is a debilitating condition that persists long after the inciting stimulus subsides. Chronic neuropathic pain that develops following damage or disease of the nervous system is partially treated by curr...