The objective of the current study was to develop and optimize a novel lyophilized liposomal formulation anticancer agent carmustine, or bis-chloroethyl nitrosourea (BCNU) for prolonged release that could overcome dose-dependent side effects improve its bioavailability at site action. optimization done using 32 factorial design approach wherein soya phosphatidylcholine (SPC) cholesterol (CH) as...

Advanced model-based experiment design techniques are a reliable tool for rapid development and refining of process models. Through two practical case studies, we demonstrate the validity of this approach as applied to planning of optimal experiments for complex kinetics elucidation. The need for an appropriate use of these tools, in particular a judicious problem formulation, is highlighted. A...