The novel bicyclo thieno 1, 2, 3-triazines (BTT) namely BTT-1, BTT-2, BTT-3 and BTT-4 were evaluated for analgesic anti-inflammatory and antiarthritic activity. Analgesic and anti-inflammatory activity was evaluated using hot plate test , formalin induced paw licking test and formalin induced paw edema test respectively, complete fruend’s adjuvant (CFA) induced arthritis model was used for anti...

avian influenza is one of the most important diseases in avian industry, which also threats human population. thus, vaccination is necessary for controlling this viral disease. in this study, killed vaccine of avian influenza subtype h9n2 and formalin solution (for virus inactivation) were used. it is necessary to study the effect of different factors such as formalin concentration, as well as ...

background: the present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. methods: food was withdrawn 48 h prior to performing the formalin test, but water continued to be ava...

We evaluated the safety and potency of Kyasanur Forest disease (KFD) vaccine inactivated with different formalin concentrations in mice, since side effects due to higher have been a major reason for refusal. Furthermore, an objective reduce use mice testing, we performed quantification KFD virus by real-time PCR compared it vivo titration mice. The prepared chicken embryo fibroblast cells was 0...

In this study, IP administration of acetaminophen and its half-life were investigated. Acetaminophen as an analgesic drug ordinarily is used in tablets or syrup form. Therefore, there is no report about administration of acetaminophen through injection. Acetaminophen in ED50 dose (200 mg/kg) was injected into the animals intraperitoneally, and its analgesic effect was investigated by formalin t...

Introduction: Previously, we demonstrated that i.p. injection of aqueous extract prepared from aerial parts of Drosera Spatulata (Droseraceae) can induced remarkable analgesia in both phases of formalin test in rats. Because, analgesia induced in acute phase of formalin test mainly mediated by activation of central analgesic mechanisms and also paragigantocellularis (PGi) nucleus is part of bra...