The crystal structure of pimecrolimus Form B has been solved and refined using synchrotron X-ray powder diffraction data optimized density functional techniques. Pimecrolimus crystallizes in the space group P 2 1 (#4) with a = 15.28864(7), b 13.31111(4), c 10.95529(5) Å, β 96.1542(3)°, V 2216.649(9) Å 3 , Z 2. Although there are an intramolecular six-ring hydrogen bond some larger chain ring pa...

background: restless legs  syndrome  (rls)  is the  most common movement disorder in pregnancy, which can be idiopathic  or secondary. there are  limited  comparative data  regarding  these  two forms of rls.  the aim of this study was to compare  clinical features  of idiopathic  and secondary rls in pregnant women. methods: over a period  of 3 months, 443 women  who admitted for delivery in t...

As the pilgrims and tourists have been always present in Mashhad, meeting their needs has been constantly prioritized in urban planning especially the renewal and reconstruction projects carried out in the holy shrine surroundings. However, recent years have seen a change of perspective toward pilgrims. These changes have been induced by both global and national politics. That is why great chan...

rapid urban population is widely known as the main inducement of growing cities in terms of quantity and variety in form. however, the city expansion entails physical challenges and it has profound impacts on the issue of urban morphology. it raises global awareness beyond the urbanism and includes sociology, psychology, economics as well as environmental studies due to the implications of broa...