نتایج جستجو برای: foot and mouth disease vius

تعداد نتایج: 17065657  

Journal: :Vaccine 2011
Eduardo Maradei Claudia Perez Beascoechea Viviana Malirat Gustavo Salgado Cristina Seki Andrea Pedemonte Paula Bonastre Ricardo D'Aloia José L La Torre Nora Mattion Jorge Rodríguez Toledo Ingrid E Bergmann

During the years 2009 and 2010 relevant epidemic waves of foot-and-mouth disease (FMD) serotype O occurred in Ecuador, representing a great drawback for the last stages of the ongoing eradication program in South America. This study describes the molecular and antigenic characterizations of 29 isolates collected from various regions in the country and their relationship to the vaccine strain. T...

Journal: :Nucleic acids research 1987
D V Sangar S E Newton D J Rowlands B E Clarke

Translation of the foot and mouth disease virus genome in vitro and in vivo indicated that all seven serotypes initiate protein synthesis at two separate AUGs. Sequence analysis of the region surrounding these AUGs has shown that the efficiency with which the initiating AUG is recognized is dependent on the flanking nucleotides. However, in vitro, the major factor determining which AUG is used ...

Journal: :Genetic Vaccines and Therapy 2004
Pablo de Felipe

The rapid progress in the field of genomics is increasing our knowledge of multi-gene diseases. However, any realistic hope of gene therapy treatment for those diseases needs first to address the problem of co-ordinately co-expressing several transgenes. Currently, the use of internal ribosomal entry sites (IRESs) is the strategy chosen by many researchers to ensure co-expression. The large siz...

2017
Le T Vu Ngo T Long Barbara Brito Carolina Stenfeldt Nguyen T Phuong Bui H Hoang Steven J Pauszek Ethan J Hartwig George R Smoliga Pham P Vu Le T V Quang Vo V Hung Nguyen D Tho Pham V Dong Phan Q Minh Miranda Bertram Ian H Fish Luis L Rodriguez Do H Dung Jonathan Arzt

In recent years, foot-and-mouth disease virus (FMDV) serotype O, topotype Middle East-South Asia (ME-SA), lineage Ind-2001d has spread from the Indian subcontinent to the Middle East, North Africa, and Southeast Asia. In the current report, we describe the first detection of this lineage in Vietnam in May, 2015 in Đắk Nông province. Three subsequent outbreaks caused by genetically related virus...

2015
Zhidong Zhang Claudia Doel John B. Bashiruddin

The factors leading to persistent infection of foot-and-mouth disease (FMD) virus in ruminants are not well defined. This paper provides evidence of the presence of interleukin-10 (IL-10) early in the course of infection (1-4 days) as a factor in the development of persistence of FMD virus in cattle. Results showed that serum IL-10 in carrier cattle infected with FMD virus type O (n = 4) was de...

Journal: :The Journal of general virology 1991
M D Ryan A M King G P Thomas

The 2A region of the foot-and-mouth disease virus (FMDV) polyprotein is only 16 amino acids in length. During synthesis of the FMDV polyprotein a primary proteolytic processing event occurs between the 2A and 2B regions of the polyprotein. The activity responsible for this cleavage is not known but it is thought that either an unidentified virus-encoded proteinase may be responsible, or that 2A...

Journal: :Revue scientifique et technique 2012
B Asseged B Tameru D Nganwa R Fite T Habtemariam

The trade of livestock or their products between nations requires information on the risk of introducing infectious agents such as foot and mouth disease virus (FMDV). Although transmission pathways for FMDV vary, a recent concern in the United States (USA) is that it might enter via cloned embryos. A quantitative risk assessment model was developed to determine the scenarios (with mathematical...

2015
Rae-Hyung Kim Jia-Qi Chu Jeong-Nam Park Seo-Yong Lee Yeo-Joo Lee Mi-Kyeong Ko Ji-Hyeon Hwang Kwang-Nyeong Lee Su-Mi Kim Dongseob Tark Young-Joon Ko Hyang-Sim Lee Min-Goo Seo Min-Eun Park Byounghan Kim Jong-Hyeon Park

We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vac...

2015
Sokkosal Chea Yi-bing Cheng Kulkanya Chokephaibulkit Tawee Chotpitayasunondh H. Rogier van Doorn Zen Hafy Surinda Kawichai Ching-Chuan Liu Nguyen Tran Nam Mong How Ooi Marcel Wolbers Mei Zeng

The South East Asia Infectious Disease Clinical Research Network convened subject matter experts at a workshop to make consensus recommendations for study design of a clinical trial for use of intravenous immunoglobulin (IVIg) in severe hand, foot and mouth disease (HFMD). HFMD is a highly contagious emerging infection among children in the region, a small proportion of whom develop neurologic ...

Journal: :Journal of virology 1987
E Beck K Strohmaier

The VP1-coding regions of foot-and-mouth disease virus strains from 18 recent European outbreaks and of 9 strains isolated more than 20 years ago and used in part as vaccines were determined by direct cDNA sequencing. Comparison of the sequences revealed that most of the isolated outbreak viruses are closely related to the vaccine strains used. Isolates from the Italian epizootic of 1984 to 198...

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