BACKGROUND Risk of thyroid cancer has already been related to refined cereals and starch food, but the association has not been studied in terms of glycemic index (GI) and glycemic load (GL). PATIENTS AND METHODS We analyzed data from a case-control study conducted in Italy from 1986 to 1992 and including 399 histologically confirmed and incident cases of thyroid cancer and 616 control subjec...

The aim of this study was to evaluate the usefulness of fine-needle aspiration cytology (FNAC) and (99m)Tc-pertechnetate scintigraphy (TS) together in patients with differentiated thyroid carcinoma. Data from a series of 357 patients (284 women and 73 men, median age 43 years, range 19-73) with solitary thyroid nodule and no signs of hyperfunction, who had undergone both FNAC and TS prior to su...

Many clinical studies highlight the dichotomous role of PRDXs in human cancers, where they can exhibit strong tumor-suppressive or tumor-promoting functions. Recent evidence suggests that lower expression of PRDXs correlates with cancer progression in colorectal cancer (CRC) or in esophageal squamous carcinoma. In the thyroid, increased levels of PRDX1 has been described in follicular adenomas ...

INTRODUCTION Thyroid cancer is the most common among all endocrine malignancies. The worldwide prevalence of goitre in the general population is estimated at 4-7 percent and the incidence of malignancy in goitrous thyroid is about ten percent. It is postulated that goitrous thyroid is a precursor lesion to the development of malignant thyroid diseases. As Sarawak is a state well known for endem...

CONTEXT Thyroid cancer cells express TSH receptor (TSHR) mRNA, and its measurement in the circulation may be useful in the diagnosis/management of differentiated thyroid cancer (DTC). OBJECTIVE Our objective was to assess the diagnostic value of circulating TSHR mRNA for preoperative detection of DTC in patients with thyroid nodules. PATIENTS We measured TSHR mRNA levels by RT-PCR in 258 su...

four patients are described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. it is possible that the initial thyroid neoplasm was a well- differentiated follicular carcinoma which was microscopically indistinguishable from a benign adenoma. realizing this pathologic pitfall in thyroid diagnosis, the need for meticulous examination of the patholo...

Aurora-A kinase has recently been shown to be deregulated in thyroid cancer cells and tissues. Among the Aurora-A substrates identified, transforming acidic coiled-coil (TACC3), a member of the TACC family, plays an important role in cell cycle progression and alterations of its expression occur in different cancer tissues. In this study, we demonstrated the expression of the TACC3 gene in norm...

Abbreviations : ATRA, all-trans-retinoic acid ; DTC, differentiated thyroid cancer ; FTC, follicular thyroid carcinoma ; NIS, Na/I symporter ; NF-kappaB, nuclear factor kappaB; RA, retinoic acid ; RAR, retinoic acid receptor ; RARE, retinoic acid response element ; RXR, retinoid X receptor ; TG, thyroglobuline ; TPO, thyroid peroxydase ; TSHR, thyroid stimulating hormone receptor ; PAX8, paired...

Around 1500 new cases of thyroid cancer are diagnosed each year in the United Kingdom, being responsible for around 320 deaths annually. Detecting recurrent thyroid carcinoma is important for the speedy imposition of treatment regimens, but occasionally detecting subsequent disease can be problematic. Bone is the commonest site for distant thyroid carcinoma metastases, but other sites such as t...

Around 1500 new cases of thyroid cancer are diagnosed each year in the United Kingdom, being responsible for around 320 deaths annually. Detecting recurrent thyroid carcinoma is important for the speedy imposition of treatment regimens, but occasionally detecting subsequent disease can be problematic. Bone is the commonest site for distant thyroid carcinoma metastases, but other sites such as t...