Physical activity (PA) may need to produce high impacts to be osteogenic. The aim of this study was to identify threshold(s) for defining high impact PA for future analyses in the VIBE (Vertical Impact and Bone in the Elderly) study, based on home recordings with triaxial accelerometers. Recordings were obtained from 19 Master Athlete Cohort (MAC; mean 67.6 years) and 15 Hertfordshire Cohort St...

Fatty liver (FL) is one of the most prevalent diseases in world, characterized by insulin resistance and hyperlipidemia, which consequently lead to neurodegenerative disorders through induction oxidative stress-inflammatory axis, alters neurotransmitters’ levels. Calluna vulgaris (CV), also known as heather, has anti-inflammatory antidepressant properties, making it a promising candidate for tr...

Changing the internal structure of a program without changing its behavior is called restructuring. This paper presents a transformation called tuck for restructuring programs by decomposing large functions into small functions. Tuck consists of three steps: Wedge, Split, and Fold. A wedge—a subset of statements in a slice—contains computations that are related and that may create a meaningful ...

UNLABELLED The clinical utility of the adeno-associated virus (AAV) gene delivery system has been validated by the regulatory approval of an AAV serotype 1 (AAV1) vector for the treatment of lipoprotein lipase deficiency. However, neutralization from preexisting antibodies is detrimental to AAV transduction efficiency. Hence, mapping of AAV antigenic sites and engineering of neutralization-esca...

In recent years studies have been initiated on a new class of multipole field generators consisting of cuboid planar permanent magnet (PM) pieces arranged in biplanar arrays of 2-fold rotational symmetry. These structures, first introduced for Free Electron Laser (FEL) applications, are based on reducing the rotational symmetry of conventional N-pole field generators from N-fold to 2-fold. One ...

The ligand binding domain of glutamate receptors (GluRs) has 2-fold rotational symmetry. The structure including the symmetry of the GluR ion channel remains undefined. Here we used substituted cysteines in the pore-lining M3 segment of the AMPAR GluR-A subunit and various cysteine-reactive agents to study the structure of the channel during gating. We find that cysteines substituted at A+6, lo...

For internal rotation in 3-fold tops, the internal axis system (lAS) has been a great convenience because the vibrational angular momentum is constant and is directed along a single axis. A procedure for finding an IAS for the general asymmetric top-asymmetric frame case is given. This procedure is an existence proof that such an axis system can be found. Once the IAS is found, details will be ...

Abstract Coherence is one of the limiting factors in off-axis electron holography applications. This paper reports methods to improve coherence ∼18-fold by using a smaller biprism and implementing direct counting camera (K-camera) combination with an imaging filter system. We achieved 0.4 nm fringe spacing 1.5 μm field-of-view ∼33% contrast. The maximum number, N′, ∼1.8 × 103 was achieved, wher...