Levodopa withdrawal and the neuroleptic malignant syndrome Sir, In the paper: 'Levodopa withdrawal syndrome identical to neuroleptic-malignant syndrome' (Gibb & Griffith, 1986) the authors suggested that sudden withdrawal of dopaminergic drugs precipitated the development of neuroleptic-malignant syndrome (NMS) in their patient. However, it is difficult to reconcile the wide range of this patie...

Three patients, one male and two females who developed neuroleptic malignant syndrome following exposure to depot and oral neuroleptic are presented. The patients satisfied Levenson's criteria for diagnosis. Bromocriptine and Electro Convulsive Therapy were found effective whereas trihexyphenidyl proved unsatisfactory in the treatment. All the patients recovered completely without complications.