نتایج جستجو برای: fluoxetine
تعداد نتایج: 3720 فیلتر نتایج به سال:
Background : Long-term exposure to anxiety and depression puts myocardium at risk of failure. Neurohormone Message caused be depression delivered to the heart by beta1 adrenoreceptor. The aim of this study was to survey and compare the effect of 4 weeks of endurance training with fluoxetine treatment on beta-adrenergic receptors in the male Wistar rat heart. Materials and Methods: This researc...
The precise neurochemical effects of antidepressants that underlie their efficacy remain unclear. Many antidepressants modulate noradrenaline transmission in vivo. However, the selective serotonin reuptake inhibitors (SSRIs) and NK1 receptor antagonists target 5-HT and substance P transmission, respectively. Whether effects on noradrenaline neurones contribute to the efficacy of these drugs has...
The purpose of this study was to compare the efficacy of the cognitive-behavior therapy (CBT), exposure and response prevention (ERP) and Fluoxetine in the obsessive-compulsive patients. The experimental design was selected and 59 patients with obsessive-compulsive disorder (OCD) diagnosis were randomly assigned to 4 groups: cognitive-behavioral therapy, exposure and response prevention, Fluoxe...
Fluoxetine is a selective serotonin reuptake inhibitor that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus-pituitary-adrenal. However, it is not yet established whether fluoxetine can modulate the responses to stressors stimulants (physical or chemical) that trigger cortisol respons...
CORRESPONDENCE Fluoxetine oral administration increases intraocular pressure EDITOR,-Fluoxetine is a widely prescribed antidepressant which acts as a selective inhibi-tor of neuronal serotonin uptake.' Recently, Ahmad2 reported on a case of acute narrow angle glaucoma due to fluoxetine administration. For this purpose, we verified the intraocular pressure (IOP) variations in 20 consecutive depr...
The aim of the present study was to investigate the effect of the distribution interaction between thioridazine and fluoxetine in vivo. Experiments were carried out on male Wistar rats. Animals received thioridazine and fluoxetine separately or jointly, at a dose of 10 mg/kg ip. Concentrations of thioridazine and its metabolites and fluoxetine in the plasma and tissues were measured at 1 h afte...
Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...
INTRODUCTION Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS. Advances in drug discovery have widened the therapeutic options with the synthesis of so-called selective serotonin reuptake inhibitors (SSRIs),...
In the present study was examined the effect of treatment with olanzapine or risperidone, given separately or in combination with fluoxetine, in the elevated plus-maze test (an animal model of anxiety) in male Wistar rats. The obtained results showed that treatment with olanzapine (1 mg/kg), risperidone (0.1 and 0.3 mg/kg) or fluoxetine (5 and 10 mg/kg) induced an anxiolytic-like effect in the ...
OBJECTIVE Administration of placebo can result in a clinical response indistinguishable from that seen with active antidepressant treatment. Functional brain correlates of this phenomenon have not been fully characterized. METHOD Changes in brain glucose metabolism were measured by using positron emission tomography in hospitalized men with unipolar depression who were administered placebo as...
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