www.onk.ns.ac.rs/Archive Vol 20, No. 3-4, December 2012 PET IMAGING IN ESOPHAGEAL CARCINOMA Esophageal carcinoma is a relatively rare disease with approximately 13,200 new cases detected in 2001 in the United States (1). It is most common between 50 and 60 years of age with a male to female ratio of 4:1 (2). According to the SEER database, an annual age-adjusted incidence rate is 4.5 per 100,00...

BACKGROUND To validate a gradient-based segmentation method for gross tumor volume(GTV) delineation on (8)F-fluorothymidine (FLT)positron emission tomography (PET)/ computer tomography (CT) in esophageal squamous cell cancer through pathologic specimen, in comparison with standardized uptake values (SUV) threshold-based methods and CT. The corresponding impact of this GTV delineation method on ...

The adenoviral E1A CR2 mutant dl922-947 has potent activity in ovarian cancer. We have used Renilla luciferase bioluminescence imaging to monitor viral E1A expression and replication and [18F]fluorothymidine positron emission tomography ([18F]FLT-PET) to quantify the activity of dl922-947 in vivo. We created dlCR2 Ren, with the same E1A CR2 deletion as dl922-947 and the luciferase gene from Ren...

PURPOSE To evaluate the feasibility of early metabolic change assessed by PET in predicting clinical response to chemotherapy and investigate its prognostic value in patients with advanced gastric cancer. EXPERIMENTAL DESIGN A total of 64 patients with advanced gastric cancer were prospectively enrolled and examined by PET with (18)F-fluorodeoxyglucose (FDG) and (18)F-fluoro-3'-deoxy-3'-L-flu...

BACKGROUND We observed a disproportional 18 F-fluorothymidine (F-FLT) uptake in follicular lymphoma (FL) relative to its low cell proliferation. We tested the hypothesis that the 'excess' uptake of 18 F-FLT in FL is related to error-prone DNA repair and investigated whether this also contributes to 18 F-FLT uptake in diffuse large B cell lymphoma (DLBCL). METHODS We performed immunohistochemi...

For several decades, cytotoxic chemotherapeutic agents were considered the basis of anticancer treatment for patients with metastatic tumors. A decrease in tumor burden, assessed by volumetric computed tomography and magnetic resonance imaging, according to the response evaluation criteria in solid tumors (RECIST), was considered as a radiological response to cytotoxic chemotherapies. In additi...

Abstract Objective PET scans are useful for the diagnosis and treatment planning of glioma. Introduced in 2013, bevacizumab (Bev) efficacy can be difficult to determine using MRI imaging. We instead performed Bev-based glioblastoma treatment. Methods Eighty patients treated with Bev from July 2013 December 2021 were included. The divided into following three groups: first group received added S...