INTRODUCTION Interleukin (IL)-27 is a novel member of the IL-6/IL-12 family cytokines that are produced early by antigen-presenting cells in T helper (Th)1-mediated inflammation. Elevated expression of IL-27 has been detected in the synovial membranes and fluid of rheumatoid arthritis (RA). METHODS We investigated the in vitro effects of IL-27, alone or in combination with inflammatory cytoki...

BACKGROUND It has been hypothesized that chronic inflammatory diseases such as rheumatoid arthritis (RA) may be caused by a failure of negative feedback mechanisms. This study sought to examine negative feedback mechanisms in fibroblast-like synoviocytes (FLS), one of the most abundant cell types in the joint. We hypothesized that prior exposure of healthy FLS to an inflammatory stimulus would ...

STUDY DESIGN Cross-sectional study. PURPOSE To translate and validate the Fukushima lumbar spinal stenosis (LSS) scale 25 (FLS-25) for use in Iran. OVERVIEW OF LITERATURE Tools measuring patient-reported outcomes should satisfy certain psychometric properties. METHODS FLS-25 is a self-administered scale for evaluating symptoms of LSS. A forward-backward procedure was applied to translate ...

INTRODUCTION The microenvironment surrounding inflamed synovium leads to the activation of fibroblast-like synoviocytes (FLSs), which are important contributors to cartilage destruction in rheumatoid arthritic (RA) joints. Transglutaminase 2 (TG2), an enzyme involved in extracellular matrix (ECM) cross-linking and remodeling, is activated by inflammatory signals. This study was undertaken to as...

Recent reports associate teachers’ turnover intentions as a response to disruptions and transition of the teaching-learning process (e.g., flexible learning) due COVID-19 pandemic. This study explores antecedents intention teach in learning system (FLS) their via an extended theory planned behavior (TPB). Using cross-sectional survey, 417 valid responses were analyzed model this phenomenon, wit...

The main cause of fatal accidents in the construction sector are falls from height (FFH) and inappropriate use a harness is commonly associated with these fatalities. Traditional methods, such as onsite inspections, safety communication, or training, not enough to mitigate caused by FFH poor management harness. Although some technological solutions for automated monitoring workers could improve...

INTRODUCTION It is well known that neutrophils play very important roles in the development of rheumatoid arthritis (RA) and interleukin (IL)-8 is a critical chemokine in promoting neutrophil migration. We previously showed that increased production of Cyr61 by fibroblast-like synoviocytes (FLS) in RA promotes FLS proliferation and Th17 cell differentiation, thus Cyr61 is a pro-inflammatory fac...

In this paper, we review some classical recombination operations and devise new heuristic recombinations for the fixed-length subset. Our experimental results on the classical p-median problem indicate that our method is superior and very close to the optimal solution. 1 Fixed-Length Subset Recombinations We study the Fixed Length Subset Genetic Algorithm (FLS-GA), whose candidate solutions are...

The rapid adoption of robotic assisted surgery challenges the pace at which adequate robotic training can occur due to access limitations to the da Vinci robot. Thirty medical students completed a randomized controlled trial evaluating whether the Raven robot could be used as an alternative training tool for the Fundamentals of Laparoscopic Surgery (FLS) block transfer task on the da Vinci robo...

We describe a computationally designed enzyme, formolase (FLS), which catalyzes the carboligation of three one-carbon formaldehyde molecules into one three-carbon dihydroxyacetone molecule. The existence of FLS enables the design of a new carbon fixation pathway, the formolase pathway, consisting of a small number of thermodynamically favorable chemical transformations that convert formate into...