We review and compare our experience with tricuspid ring annuloplasty between usage of the Cosgrove-Edwards flexible band and the MC(3) rigid ring for repair of functional tricuspid regurgitation to determine the efficacy and mid-term durability of tricuspid annuloplasty. 117 patients with functional tricuspid regurgitation undergoing open heart surgery and tricuspid valve repair from May 2005 ...

The guanine dissociation inhibitors RhoGDI and D4GDI inhibit guanosine 5'-diphosphate dissociation from Rho GTPases, keeping these small GTPases in an inactive state. The GDIs are made up of two domains: a flexible N-terminal domain of about 70 amino acid residues and a folded 134-residue C-terminal domain. Here, we characterize the conformation of the N-terminal regions of both RhoGDI and D4GD...

linear dynamic response of simply supported nanobeams subjected to a variable axial force is assessed by galerkin numerical approach. constitutive behavior is described by three functional forms of elastic energy densities enclosing nonlocal and strain gradient effects and their combination. linear stationary dynamics of nanobeams is modulated by an axial force which controls the global stiffne...

in this article differential transformation method (dtms) has been used to solve neutral functional-differential equations with proportional delays. the method can simply be applied to many linear and nonlinear problems and is capable of reducing the size of computational work while still providing the series solution with fast convergence rate. exact solutions can also be obtained from the kno...

The functional response is a key element in all predator-prey interactions. Although functional responses are traditionally modelled as being a function of prey density only, evidence is accumulating that predator density also has an important effect. However, much of the evidence comes from artificial experimental arenas under conditions not necessarily representative of the natural system, an...

one of the most important and valuable goal of software development life cycle is software cost estimation or sce. during the recent years, sce has attracted the attention of researchers due to huge amount of software project requests. there have been proposed so many models using heuristic and meta-heuristic algorithms to do machine learning process for sce. cocomo81 is one of the most popular...

Media mix models are used by advertisers to measure the effectiveness of their advertising and provide insight in making future budget allocation decisions. Advertising usually has lag effects and diminishing returns, which are hard to capture using linear regression. In this paper, we propose a media mix model with flexible functional forms to model the carryover and shape effects of advertisi...

The RNA splicing and processing endonuclease from Nanoarchaeum equitans (NEQ) belongs to the recently identified (alphabeta)(2) family of splicing endonucleases that require two different subunits for splicing activity. N. equitans splicing endonuclease comprises the catalytic subunit (NEQ205) and the structural subunit (NEQ261). Here, we report the crystal structure of the functional NEQ enzym...