نتایج جستجو برای: flavonoids dna interactions

تعداد نتایج: 889057  

Journal: :Carcinogenesis 1996
C Malaveille A Hautefeuille B Pignatelli G Talaska P Vineis H Bartsch

Human urine is known to contain substances that strongly inhibit bacterial mutagenicity of aromatic and heterocyclic amines in vitro. The biological relevance of these anti-mutagens was examined by comparing levels of tobacco-related DNA adducts in exfoliated urothelial cells from smokers with the anti-mutagenic activity in corresponding 24-h urine samples. An inverse relationship was found bet...

Journal: :Phytochemical analysis : PCA 2013
Karen M Vandermolen Nadja B Cech Mary F Paine Nicholas H Oberlies

INTRODUCTION Grapefruit juice can increase or decrease the systemic exposure of myriad oral medications, leading to untoward effects or reduced efficacy. Furanocoumarins in grapefruit juice have been established as inhibitors of cytochrome P450 3A (CYP3A)-mediated metabolism and P-glycoprotein (P-gp)-mediated efflux, while flavonoids have been implicated as inhibitors of organic anion transport...

Journal: :Mutagenesis 2006
G Cantero C Campanella S Mateos F Cortés

Luteolin and quercetin are widely distributed plant flavonoids that possess a variety of chemical and biological activities, including free-radical scavenging and antioxidant activity. Recently, both flavonoids have been reported to inhibit DNA topoisomerases I and II (topo I and topo II), a property that, together with their ability to induce DNA and chromosome damage, has made them candidate ...

2015
Rafael Baptista Ana Margarida Madureira Rita Jorge Rita Adão Aida Duarte Noélia Duarte Maria Manuel Lopes Generosa Teixeira

The antioxidant and antimycotic activities of the essential oils and extracts of two native Portuguese Lavandula species, L. stoechas subsp. luisieri and L. pedunculata, were evaluated by in vitro assays. The total phenolics and flavonoids content were also determined. The antioxidant potential was assessed through DPPH radical scavenging, inhibition of lipid peroxidation (ILP), and DNA protect...

Journal: :International Journal of Molecular Sciences 2021

In plant ecology, biochemical analyses of bryophytes and vascular plants are often conducted on dried herbarium specimen as species typically grow in distant inaccessible locations. Here, we present an automated silico compound classification framework to annotate metabolites using untargeted data independent acquisition (DIA)–LC/MS–QToF-sequential windowed all theoretical fragment ion mass spe...

Journal: :iranian journal of pharmaceutical research 0
j hanaee mr rashidi delazar a s piroozpanah

onion (allium cepa) contains high levels of flavonoids. although there are many studies indicating the inhibitory effects of flavonoids on xanthine oxidase, there is no report on the effect of onion on this enzyme. therefore, in the present study, the inhibitory effects of onion on xanthine oxidase are investigated. fresh filtered juice of onion was prepared and its inhibitory effect on guinea ...

2003
Jane Anastassopoulou

Metal ions can bind to DNA directly or indirectly through hydrogen bonding of the coordinating water molecules surrounding the metal ions. Metal binding to the bases usually disrupts base pair hydrogen bonding and destabilizes the double helix. Spectroscopic and X-ray data shows that the N7 atom of the purine or N3 of pyrimidine residues as well as exocyclic O atoms and the phosphate oxygen ato...

Journal: :Plant foods for human nutrition 2004
L H Yao Y M Jiang J Shi F A Tomás-Barberán N Datta R Singanusong S S Chen

There has been increasing interest in the research of flavonoids from dietary sources, due to growing evidence of the versatile health benefits of flavonoids through epidemiological studies. As occurrence of flavonoids is directly associated with human daily dietary intake of antioxidants, it is important to evaluate flavonoid sources in food. Fruits and vegetables are the main dietary sources ...

Journal: :FEBS Letters 2021

The DEK oncoprotein regulates cellular chromatin function via a number of protein–protein interactions. However, the biological relevance its unique pseudo-SAP/SAP-box domain, which transmits DNA modulating activities in vitro, remains largely speculative. As hypothesis-driven mutations failed to yield DNA-binding null (DBN) mutants, we combined random mutagenesis with Bacterial Growth Inhibiti...

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