Two new chalcones, 3-hydroxy-3',4'-dimethoxychalcone (1) and 3,2'-dihydroxy-3',4'-dimethoxychalcone (2), were isolated from the flowers of Clerodendrum inerme (L.) Gaertn together with two known flavones, 7-O-methylwogonin (3) and eucalyptin (4). The structures of the new compounds 1 and 2 have been established by extensive 2D-NMR and ESI-TOFMS studies.

6, 8–trimethoxy Flavone and 3, 5–dihydroxy-6, 7, 8–trimethoxy Flavone Concentrations in Rat Colon Tissue C. L. Whitted, V. E. Palau, R. D. Torrenegra, O. E. Rodriguez, S. Harirforoosh East Tennessee State University, Universidad de Ciencias Aplicadas y Ambientales, Universidad del Bosque Purpose In vitro antineoplastic activity against colon cancer cell lines has been previously shown [1]for is...

stachys genus with medicinal properties and high polymorphic features has been considered oneof the largest genera of lamiaceae. the aim of this study was to determine the flavonoid patternvariations and flavonoid groups in ten stachys species belonging to two sections; fragilicaulis,and aucheriana. the studied species were collected from natural habitats in iran and analysedfor their flavonoid...

Background: The predominant etiology for erectile dysfunction (ED) is vascular, but limited data are available on the role of diet. A higher intake of several flavonoids reduces diabetes and cardiovascular disease risk, but no studies have examined associations between flavonoids and erectile function. Objective: This study examined the relation between habitual flavonoid subclass intakes and i...

Flavones are a major class of flavonoids with a wide range of physiological functions in plants. They are constitutively accumulated as C-glycosides and O-linked conjugates in vegetative tissues of grasses. It has long been presumed that the two structural modifications of flavones occur through independent metabolic routes. Previously, we reported that cytochrome P450 93G2 (CYP93G2) functions ...

Three methods are utilized to synthesize a variety of 6,8-di-C-glycosylflavones bearing identical or distinct glycosyl moieties. Some C-glycosylation compounds are found to have better anti-inflammation activities than the parent flavones. Among them, 6,8-di-C-glucosylapigenin (known as vicenin-2) shows inhibition of TNF-alpha expression and NO production with IC(50) values of 6.8 and 5.2 muM, ...

Eubacterium cellulosolvens cleaved the flavone C-glucosides homoorientin and isovitexin to their aglycones luteolin and apigenin, respectively. The corresponding isomers, orientin and vitexin, or other polyphenolic C-glucosides were not deglycosylated. E. cellulosolvens also cleaved several O-coupled glucosides of flavones and isoflavones to their corresponding aglycones.

A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC(50) 5.0 microg/mL.