The first aim of this study is to characterize the reduction of progesterone in rat liver. Progesterone was mainly reduced to 20alpha-hydroxyprogesterone in the cytosolic fraction of rat liver. The amount of 20alpha-hydroxyprogesterone formed from progesterone in the cytosolic fraction was significantly larger in the males than in the females and this enzyme reaction proceeded not only in the p...

Sistem kekebalan adalah sistem pertahanan tubuh, yang bertujuan untuk mengenali dan merespons dari berbagai macam patogen atau cedera melindungi tubuh. imun dapat mengalami ketidakseimbangan berdampak pada inflamasi tidak terkontrol menyebabkan penyakit. Dalam mengatasinya diperlukan imunomodulator antiinflamasi. Tumbuhan memiliki efek antiinflamasi yaitu tumbuhan meniran (genus Phyllanthus). D...

Transforming growth factor-beta (TGF-β) plays a crucial role in cancer during development and metastasis. The TGF-β signaling pathway begins with the binding of active to receptor type II, which ultimately leads expression target genes nucleus. In this study, 56 compounds from Allium cepa were docked against transforming I II (TGFBR II) identify small molecular weight capable firmly kinase doma...