first degree relatives

BACKGROUND Mild tremor may occur in relatives of patients with essential tremor (ET). However, this phenomenon has not been studied quantitatively or with a comparison group. Such a study may provide information on the penetrance of ET. OBJECTIVE To obtain data on the magnitude of tremor in case and control relatives who did not meet diagnostic criteria for ET. METHODS Cases with ET and con...

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Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.

Journal: :Cancer prevention research 2012

A Joan Levine Aung Ko Win Daniel D Buchanan Mark A Jenkins John A Baron Joanne P Young Tiffany I Long Daniel J Weisenberger Peter W Laird Rebecca L McCall David J Duggan Robert W Haile

Methylation of the MLH1 gene promoter region is an underlying cause of colorectal cancer (CRC) with high microsatellite instability (MSI-H) diagnosed in persons without a germ line mutation in a mismatch repair (MMR) gene (non-Lynch Syndrome CRC). It is unclear whether relatives of CRC cases with MLH1 methylation have an increased risk of colorectal or other cancers. In this retrospective cohor...

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