Our aim in this study was to observe the movements of filarial infective larvae following inoculation into the mammalian host and to assess the effect of vaccination on larval migration, in situ. Here we present recordings of larvae progressing through the subcutaneous tissues and inguinal lymph node of primary infected or vaccinated mice. We used the filaria Litomosoides sigmodontis in BALB/c ...

This is a reprint of various lectures delivered by the Author on different occasions and of some papers contributed to the medical press. The Lettsomian Lectures on tropical dysentery and diarrhoea delivered in 1881 make up nearly one-half of the volume. The other subjects treated of are the Bael fruit, Liver Abscess, Malarial Splenic Cachexy, Beri-Beri, Bronchocele, Elephantiasis, Arabum, Fila...

Mycobacterium tuberculosis (Mtb) and filarial coinfection is highly prevalent, and the presence of filarial infections may regulate the Toll-like receptor (TLR)-dependent immune response needed to control Mtb infection. By analyzing the baseline and mycobacterial antigen-stimulated expression of TLR1, 2, 4, and 9 (in individuals with latent tuberculosis [TB] with or without filarial infection),...

cine. Report for the year lUll. This report deals with helm initio log}', protozoology and arthropodology and contains a few pages on keratosis and climatic bubo. In lielmiiithology much work has been done on Onchocerca yibsoni, the filaria which lies coiled up in subcutaneous nodules in Australian cattle, and over which there has been an outcry in London. The worm has beeu re-examined in respe...

Human lymphatic filariasis is caused by filarial worms such as Brugia malayi for which the major reservoir is domestic cats. However, domestic cats or dogs also carry nonhuman filaria such as Brugia pahangi and Dirofilaria immitis. We have developed a single-tube, real-time PCR with a high-resolution melting (HRM) analysis assay for detection and identification of B. malayi, B. pahangi, and D. ...

The mosquito borne diseases of public health importance are complex and their occurrence depends on the interaction of various biological, ecological, social and economic factors. Though several measures for their prevention and control are followed, yet the problem density is too high with 300–500 million cases and 1.1–2.7 million deaths due to malaria alone globally per year1. Puducherry (ear...