Fibrinolysis is the process of fibrin digestion by an enzyme system present in the blood. Although fibrinolytic activity has been found in the normal, and in many pathological states, its role remains obscure. It seems likely, however, that such a process may take part in the normal hamostatic equilibrium of the body and may be operative in the processes of resolution and healing (Astrup, 1956)...

OBJECTIVES (1) To assess if patients with various forms of Raynaud's phenomenon (RP) have abnormal plasma fibrinolysis that may contribute to diminished digital blood flow; (2) to assess whether patients with RP with evidence of endothelial damage have abnormal plasma fibrinolysis; (3) to determine the clinical relevance of abnormalities, if any, in plasma fibrinolysis in patients with RP. ME...

The fibrinolytic system of a patient with congenital deficiency of a2-proteinase (plasmin) inhibitor (a2Pl) was studied. The patient’s whole blood clot formed in vitro was lysed rapidly in several hours on incubation. This accelerated in vitro fibrinolysis was suppressed by an addition of purified a2Pl. The degree of suppression was proportional to the amount of a2PI added. In spite of the acce...

The fibrinolytic system of a patient with congenital deficiency of a2-proteinase (plasmin) inhibitor (a2Pl) was studied. The patient’s whole blood clot formed in vitro was lysed rapidly in several hours on incubation. This accelerated in vitro fibrinolysis was suppressed by an addition of purified a2Pl. The degree of suppression was proportional to the amount of a2PI added. In spite of the acce...

BACKGROUND For the treatment of myocardial infarction with ST-segment elevation, primary angioplasty is considered superior to fibrinolysis for patients who are admitted to hospitals with angioplasty facilities. Whether this benefit is maintained for patients who require transportation from a community hospital to a center where invasive treatment is available is uncertain. METHODS We randoml...

BACKGROUND Only a few randomized trials have analyzed the clinical outcomes of elderly ST-segment elevation myocardial infarction (STEMI) patients (≥ 75 years old). Therefore, the best reperfusion strategy has not been well established. An observational study focused on clinical outcomes was performed in this population. METHODS Based on the national registry on STEMI patients, the in-hospita...

Fibrin/fibrinogen degradation products in the serum of 169 healthy pregnant and 43 healthy non-pregnant subjects of a similar age group showed a significant increase throughout pregnancy, the highest levels being obtained in the third trimester. There was no correlation with plasma fibrinogen levels or euglobulin lysis times. Though these changes may be due to other alterations in pregnancy not...

The author has described modern thrombolytic therapy of arterial and venous thrombosis and emboli by therapeutic fibrinolysis and other drugs also methods and effects of local and parenteral application of fibrinolysin preparations, dosage, control, indications. Contraindications, side-effects and their treatment with fibrinolysin antagonists and therapy with fibrinolysin combined with anticoag...

Two groups of volunteers were exposed to heat in a sauna bath-one group for 10 minutes and the other for 15. There was no change in plasma adrenaline concentration until the subjects emerged from the sauna bath, when there was a slight increase in concentration. Factor VIII and thrombo-elastograph patterns did not change but marked activation of fibrinolysis was stimulated by exposure to heat. ...

Purpose: We evaluate the results and complications of our intraventricular fibrinolysis protocol. Material and methods: A retrospective analysis was made of the cases of intraventricular hemorrhage with 13-bed Intensive Care Unit. Graeb score 6 or above subjected to intraventricular fibrinolysis. We gathered demographic parameters, clinical risk scores, tomography data and case histories showin...