BACKGROUND D-dimers have a high negative predictive value for excluding venous thromboembolism outside of pregnancy but the use in pregnancy remains controversial. A higher cut-off value has been proposed in pregnancy due to a continuous increase across gestation. Fibrin monomer complexes have been considered as an alternative diagnostic tool for exclusion of venous thromboembolism in pregnancy...

fibrin glue is used for control of bleeding in various surgical procedures. in this work the ability of fibrin glue to seal punctures in the vascular system is demonstrated. blood samples were taken from rabbits, fibrinogen was separated and fibrin glue was eventually prepared. the rabbits were anesthetized and a midline incision was carried out. the heart and abdominal aorta were exposed. punc...

OBJECTIVE In this work, we identified the fibrinogen sequence that on exposure serves as the primary binding site for functionally active PAI-1 and to a lesser extent for its latent form. In contrast, this site only weakly interacts with PAI-1 substrate. METHODS AND RESULTS The binding site is located in the N-terminal alpha (20-88) segment of fibrinogen, in the region exposed on (1) adsorpti...

The high-resolution crystal structure of the N-terminal central region of bovine fibrinogen (a 35-kDa E(5) fragment) reveals a remarkable dimeric design. The two halves of the molecule bond together at the center in an extensive molecular "handshake" by using both disulfide linkages and noncovalent contacts. On one face of the fragment, the Aalpha and Bbeta chains from the two monomers form a f...

Suitable alternatives are made for damaged or diseased organs and tissues in tissue engineering by combining cellular and molecular biology with materials and mechanical engineering. Fibrin is a critical blood component responsible for homeostasis, used extensively as a biopolymer scaffold in tissue engineering. This study summarizes the latest developments in organ and tissue regeneration usin...

Soluble fibronectin is found in body fluids and media of adherent cultured cells and binds to fibrin and collagen. Insoluble fibronectin is found in tissue stroma and in extracellular matrices of cultured cells. Fibronectin is a substrate for Factor XIIIa (plasma transglutaminase) and can be cross-linked by Factor XIIIa to itself and the the alpha-chain of fibrin. We used sodium dodecyl sulfate...

Given p ∈ (0, 1), we let be the random subgraph of d-dimensional hypercube Qd where edges are present independently with probability p. It is well known that, as d → ∞, if then high Qp connected; and consists one giant component together many smaller components which form “fragment”. Here fix , investigate fragment, how it sits inside hypercube. For example, give asymptotic estimates for mean n...

Background: Tissue engineering has been investigated as a potential method for healing traumatized tissues. Biomaterials are material devices or implants used to repair or replace native body tissues and organs. The present study was conducted to evaluate the effects of decontamination methods on biological/mechanical properties and degradation/adhesion test of the platelet‑-rich fibrin (PRF) m...