It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu₁ and mGlu₅ receptors together can block the induction of mossy fibre LTP. Furthermore, mossy fibre LTP can be induced by the ...

Results of an investigation of the mechanical performance of injection moulded long glass fibre reinforced polyamide 6,6 composites are presented. The glass fibre content in these composites was varied over the range 10-50% by weight using fibres with average diameters of 10, 14, and 17 micrometres. Mechanical testing and analysis of the apparent interfacial shear strength was carried out at 23...

Standard approaches to evaluate scar formation within histological sections rely on qualitative evaluations and scoring, which limits our understanding of the remodelling process. We have recently developed an image analysis technique for the rapid quantification of fibre alignment at each pixel location. The goal of this study was to evaluate its application for quantitatively mapping scar for...

PURPOSE – Conventional fibre tracking techniques estimate the fibre directions in all voxels and then use a local stepping method to track the entire pathway. However, the sensitivity of these techniques to local estimation errors is a well-known issue, as well as ambiguous fibre configurations arising from the symmetry of the DWI data [1,2]. Global fibre tracking methods [2–5], on the other ha...

Single chromosomal spindle fibres in Nephrotoma suturalis (crane-fly) spermatocytes in metaphase and anaphase were irradiated with monochromatic ultraviolet light focussed to a 2 micrometer spot. In cells in both metaphase and anaphase either the birefringence of the irradiated spindle fibre was altered in the irradiated region, or there was no change, depending on the dose and wavelength of ul...

every seifert fibre group is the lift of a fuchsian group to the universal covering group of psl (2,r). from this, we work out a form of presentation for such a group. with the calculation of the euler number, we can establish the presentation of the derived group of a seifert fibre group

Objective To investigate the association between intake of dietary fibre and whole grains and risk of colorectal cancer. Design Systematic review and meta-analysis of prospective observational studies. Data sources PubMed and several other databases up to December 2010 and the reference lists of studies included in the analysis as well as those listed in published meta-analyses. Study selection...

BACKGROUND Fermentable dietary fibre has many effects on the gastrointestinal tract. One is to alter epithelial crypt cell proliferation, especially in the colon. A discrepancy between epithelial cell production rates and intestinal weights has been noted previously: crypt cell production rates only increase if bacterial fermentation occurs, but intestinal wet weight can increase in the same an...

We examined the effects of ingestion of five types of insoluble fibre on growth and Zn absorption in rats fed a marginally Zn-deficient diet (6.75 mg (0.103 mmol) Zn/kg diet) with or without added sodium phytate (12.6 mmol/kg diet). The types of insoluble fibre tested were corn husks, watermelon skin, yam-bean root (Pachyrhizus erosus) and pineapple core, and cellulose was used as a control (10...

Diffusion-weighted imaging can potentially be used to infer the connectivity of the human brain in vivo using fibre-tracking techniques, and is therefore of great interest to neuroscientists and clinicians. A key requirement for fibre tracking is the accurate estimation of white matter fibre orientations within each imaging voxel. The diffusion tensor model, which is widely used for this purpos...