Many lines of evidence suggest that individuals with schizophrenia suffer from face processing deficits. However, the specificity of these deficits and the neural dysfunction underlying them remain unclear. To address these questions, we evaluated the functional status of a critical region for face processing, the fusiform face area (FFA), in subjects with schizophrenia. Fourteen schizophrenia ...

Primary cicatricial alopecias (PCA) are a diverse group of inflammatory hair disorders of unknown aetiology, clinically characterised by the loss of hair shafts, visible follicular ostia, and variable degrees of scalp inflammation. The hair follicle is the primary target of the disease process and persistent inflammation leads to irreversible damage to the hair follicle’s stem cells. Ultimately...

The effects of insulin on the suppression of lipolysis are neither fully understood nor quantified. We examined a variety of mathematical models analogous to the minimal model of glucose disposal (MMG) to quantify the combined influence of insulin on lipolysis and glucose disposal during an insulin-modified frequently sampled intravenous glucose tolerance test. The tested models, which include ...

It has previously been demonstrated (1) that in the postabsorptive state energy production of the heart depends largely on fatty acid metabolism; both esterified and nonesterified or free fatty acids (FFA) are taken up by the heart muscle. Although the general turnover rate of individual FFA has been studied, no investigations have been undertaken to discover their fate in the heart muscle. Aft...

Accuracy in measurement of plasma free fatty acids (FFA), and therefore prevention of the in vitro lipolysis, is a crucial step to understand the physiologic role of plasma FFA and their relationships in the pathogenesis of important metabolic disorders such as central obesity, insulin resistance, and diabetes mellitus. As lipoprotein triglyceride-fatty acids are elevated in these states, in vi...

LITTLE, JOHN R., MASAI-URO GOTO, AND JOHN J. SPITZER. E$ect of ketones on metabolism of FFA by dog myocurdium and skeletal muscle in Go. Am. J. Physiol. 219(5): 1458-1463. 1970.-The uptake of P-hydroxybutyrate (p-OHB), acetoacetate (AcAc), and free fatty acids (FFA) by the myocardium and the thigh skeIeta1 muscle of mongrel dogs was measured under control conditions and during the infusion of N...

Release of free fatty acid (FFA) from adipose tissue is implicated in insulin resistance and endothelial dysfunction in patients with visceral fat obesity. We demonstrated previously that increased FFA levels cause endothelial dysfunction that is prevented by inhibition of the renin-angiotensin system (RAS) in humans. However, the mechanisms for FFA-mediated activation of RAS and the resultant ...

This study was conducted to determine the relative rate of free fatty acid (FFA) formation and lipid oxidation of unseparated (head and broken), head, and broken rice and the effect of water washing on broken rice lipid quality. A regression model was developed with surface FFA or conjugated diene (CD) content versus incubation time to determine the rates of FFA formation and lipid oxidation. T...

Flavonoids are bioactive food compounds with potential lipid-lowering effects. Commercially available enzymatic assays are widely used to determine free fatty acid (FFA) and triglyceride (TG) levels both in vivo in plasma or serum and in vitro in cell culture medium or cell lysate. However, we have observed that various flavonoids interfere with peroxidases used in these enzymatic assays, resul...