In the present investigation we have examined the hypothesis that calcium-dependent K+ channels (K(Ca)) are involved in the sodium nitroprusside (SNP)-induced vasodilatation of goat coronary artery. SNP (10(-9)-3 x 10(-6) M), added cumulatively, relaxed K+ (30 mM)-contracted coronary artery ring segments in a concentration-dependent manner with an EC50 of 1.32 x 10(-7) M (95% CL, 0.93-1.86 x 10...

Phlomis bruguieri is a native plant in Iran, which deserves phytochemical study. The aim of this study was evaluation its iridoid contents along with antioxidant capacity. Aerial parts the material were extracted methanol and applied on repeated normal column chromatography using hexane: chloroform (70:30), chloroform: (90:10), (100%). fraction eluted (100%) containing polar glycosides selected...

The two UV screens 3-benzylidene-camphor (3-BC) and 3-(4'-methylbenzylidene)-camphor (4-MBC) were tested regarding their toxicity and estrogenic activity. The Yeast Estrogen Screen (YES) and two sediment assays with the freshwater invertebrates Lumbriculus variegatus and Potamopyrgus antipodarum were performed. In the YES, both substances activated the human estrogen receptor alpha with EC50 va...

Essential oils (EOs), as unique natural products, are promising resources for the discovery of green agrochemicals. The main ingredient geraniol citronella oil was found to exhibit substantial antifungal activities in this study. Therefore, a series novel geranyl aromatic sulfonamide compounds were synthesized and display considerable activities. Two thiofuran-sulfonamide 4c-1 (median effective...

Climate change has direct effects on aquatic systems where increased water temperature leads to range shifts and changes in the distribution of organisms. The climate ecosystems are expected all biomes, Alpine environments particular. Anthropogenic pressure (e.g., chemical pollution) besides impact state quality which environmental contaminants can interact. To better understand effect increase...

We examined the effects of the calcium channel blockers nitrendipine, diltiazem, verapamil, bepridil, and mibefradil on the cloned HERG and KvLQT1/IsK K+ channels. These channels generate the rapid and slow components of the cardiac delayed rectifier K+ current, and mutations can affect them, which leads to long QT syndromes. When expressed in transfected COS cells, HERG is blocked in a concent...

This study was conducted to investigate the influence of the saturating cation on the adsorption of parathion, methyl parathion, fenitrothion, aminoparathion, and paraoxon by montmorillonite suspensions. In all cases the saturating cation distinctly influenced the Freundlich-type adsorption, with adsorption decreasing in the following sequence: Fe—> Ca— > Na-montmorillonite. Adsorption of parat...

Estrogen receptors (ER) are nuclear hormone which responsible for sex signaling in women. A series of (1,4-disubstituted)-1,2,3-triazoles 5–21 were prepared by reaction azidophenols with terminal alkynes under Fokin conditions. The products purified column chromatography or recrystallization and characterized NMR HRMS. compounds tested binding to ERβ via a ligand displacement assay, 1-(4-hydrox...

Accumulating preclinical and clinical evidence data suggests that compounds that selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes may have therapeutic utility for the treatment of several neurological disorders. In the present study, the in vitro pharmacological properties of the novel cholinergic channel modulator ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)py...

Dose-response curves for activation of excitatory amino acid receptors on mouse embryonic hippocampal neurons in culture were recorded for 15 excitatory amino acids, including the L-isomers of glutamate, aspartate, and a family of endogenous sulfur amino acids. In the presence of 3 microM glycine, with no extracellular Mg, micromolar concentrations of 11 of these amino acids produced selective ...