Cathepsin K inhibitors have been demonstrated to restore bone mass in both animal model and postmenopausal osteoporotic patients. In the present study, we performed to investigate the pharmacological effect of icariin in the healing potential and biomechanical properties of femoral neck in a mice fractured model. The results showed that the mRNA and protein expression of cathepsin K was markedl...

INTRODUCTION The present study was performed to compare cemented total hip replacement (THR) with cemented bipolar prosthesis in the treatment of displaced fracture neck of femur in elderly patients. MATERIALS AND METHODS This prospective study included 47 patients of greater than 60 years of age and having fracture of neck of femur, out of which 25 patients were managed by cemented bipolar p...

Background: A novel modification of an existing technique was developed to allow precise fluoroscopic assessment of rotational alignment of the fractured femur during intramedullary nailing. It is hypothesized that this will reduce the incidence of rotational malalignment which is reported to occur in 20-30 % of femoral fractures managed with intramedullary nails. The neck lateral technique has...

BACKGROUND AND OBJECTIVES Drinking is a risk factor of osteoporosis, but controversy surrounds the relationship between alcohol consumption and bone mineral density (BMD). We performed an analysis of the association between alcohol consumption and BMD. METHODS AND STUDY DESIGN A cross-sectional study was performed including 2421 men, aged 40-93 years, who participated in the fourth Korea Nati...

Objective To present the clinical outcome of patients with neglected femur neck fracture treated with fibular bone graft. Methods During May 2010-February 2013, 15 patients younger than 35 years of age with neglected fracture neck of femur were managed with non-vascularized fibular graft and cannulated screws. Fractures were classified according to Sandhu Classification. Hip function was asse...

INTRODUCTION Though Gauchers disease (G.D.), a lipid storage disease is most commonly encountered by the hematologist but we present a case of G.D. type-3 which is rare in Indian subcontinent. CASE PRESENTATION A 36-year-old Hindu, Indian male patient presented with bony pain, kyphosis, dragging sensation in the abdomen, dementia and ptosis of the left eyelid for one year. Clinical examinatio...

The genetic epidemiology of variation in bone mineral density (BMD) and osteoporosis is not well studied in Iranian populations and needs more research. We report a candidate gene association study of BMD variation in a healthy cross-sectional study of 501 males and females sampled from the Iranian Multi-Centre Osteoporosis Study, Shiraz, Iran. We selected to study the association with 21 singl...

BACKGROUND The results of previous studies on the association between blood mercury (Hg) and bone mineral density (BMD) are inconsistent. We therefore used a large-scale nationwide representative sample of Korean men to investigate the relationship between these two parameters. METHODS A nationwide cross-sectional study was conducted using data from the 2008 to 2010 Korean National Health and...

UNLABELLED Twenty five pairs (50 bones) of cadaveric femora were studied morphologically and radio logically using standardized techniques to obtain anthropometric data to evaluate the applicability of internationally designed implant and to generate a database for proximal femur to help in design for future implant if these were found unsuitable. MEASUREMENTS femoral head diameter, femoral n...

Recent studies have demonstrated an important role for circulating serotonin in regulating bone mass in rodents. In addition, patients treated with selective serotonin reuptake inhibitors (SSRIs) have reduced areal bone mineral density (aBMD). However, the potential physiologic role of serotonin in regulating bone mass in humans remains unclear. Thus we measured serum serotonin levels in a popu...