The murine female reproductive tract differentiates during postnatal development. This process of cytodifferentiation and morphogenesis is dependent upon specific mesenchymal-epithelial interactions as well as circulating steroid hormones (Cunha, G.R., 1976. Int. Rev. Cytol. 47, 137-194; Pavlova, A. et al., 1994. Development 120, 335-346). Members of the Wnt family of signaling molecules have b...

To examine the distribution of sympathetic nerve fibers in the lower urinary tract, the noradrenaline content was measured in the urinary bladder dome and base, and proximal and distal urethra of the male and female dogs, using high pressure liquid chromatography-electrochemical detection (HPLC-ED). The noradrenaline content was the highest in the proximal urethra and the lowest in the urinary ...

Pregnant female mice were exposed to diethylstilbestrol or 11 beta-methoxy-17 beta-estradiol on Days 9 to 16 of gestation. The female offspring of these animals were then examined for reproductive tract abnormalities. Scanning electron microscopic and histological evaluation of these specimens demonstrated reproductive tract lesions in all treatment groups when compared to matched control mice....