the deformation modulus of a rock mass is an important input parameter in any analysis of rock mass behavior for geotechnical projects such as dams. the determination of this parameter by in situ tests are time consuming and expensive. therefore, different researchers have proposed empirical relationships for estimating the value of rock mass deformation modulus. this work has been done by usin...

PURPOSE The small GTP-binding protein Rho and its best-characterized downstream effector Rho-associated serine-threonine protein kinase, ROCK, participate in actin cytoskeleton organization, and are linked to pathogenesis and progression of several human tumors. We investigated the roles of Rho and ROCK in bladder cancer. EXPERIMENTAL DESIGN Using Western blotting, we quantitated Rho and ROCK...

PURPOSE It has been recognized that an increased expression of the Rho-associated kinase (ROCK-I), a downstream target of Rho (a Ras-related small guanosine triphosphatase [GTPase]), is associated with limbal-to-corneal epithelial transition. The purpose of the present study was to determine whether the expression of ROCK-I is regulated during the cell cycle of corneal epithelial cells. METHO...

Consider representation theory associated to symmetric groups, or to Hecke algebras in type A, or to q-Schur algebras, or to finite general linear groups in non-describing characteristic. Rock blocks are certain combinatorially defined blocks appearing in such a representation theory, first observed by R. Rouquier. Rock blocks are much more symmetric than general blocks, and every block is deri...

Slip instability and tensor instability are two kinds of failure modes of cemented waste rock backfills. In order to simulate the creep characteristics of cemented waste rock backfills, PFC was carried out. The results show that: rocks inside the models will have displacement under load. The expansion is caused by large lateral displacement of the rocks. A non-stationary creep model of cemented...

Enrichment of free mica (i.e. as monomineralic grains) in the fine fraction of crushed rock aggregates affects the quality of the aggregate end product. Granitoid rock from the Svecofennian Province were used as being representative of crushed rock aggregates commonly used for construction purposes. The results reveal a general trend of enrichment of mica for finer fractions. For the coarse gra...

Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Whereas the molecular and cellular mechanisms governing astrocytoma invasion remain poorly understood, evidence in other cell systems has implicated a role for the Rho-GTPases in cell motility and invasion. Here, we examine how the inhibition or activation of Rho-kinase (ROCK) affects astro...

Chronic pulmonary hypertension in infancy and childhood is characterized by a fixed and progressive increase in pulmonary arterial pressure and resistance, pulmonary arterial remodeling, and right ventricular hypertrophy and systolic dysfunction. These abnormalities are replicated in neonatal rats chronically exposed to hypoxia from birth in which increased activity of Rho-kinase (ROCK) is crit...

The rho-associated kinase (ROCK) signaling pathway is activated via secreted bioactive molecules or via integrin activation after extracellular matrix binding. These lead to polymerization of actin stress fibers and formation of focal adhesions. Accumulating evidence suggests that actin cytoskeleton-modulating signals are involved in aqueous outflow regulation. Aqueous humor contains various bi...