preparation of chitosan (cs) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low cs molecular weight (mw) was investigated in this study. diphtheria toxoid (dt) was used as a model antigen. the emulsion-solidification method was adopted for microencapsulation of dt.  in the first step, following the purification of semi-crude dt by the ion-exchan...

The ternary nanocomposite of silver particles decorated N/S dual-doped graphene and molybdenum disulfide microspheres (Ag-MoS 2 /NSG) is prepared by hydrothermal-chemical reduction method with quantum dots (GQDs) as additives oxide, sodium molybdate nitrate main raw materials. For comparison, the binary composites Ag-MoS , Ag-NSG MoS /NSG are also discussed. In addition, physicochemical electro...

Carvedilol (CVD) is an antihypertensive agent with a short half-life, pH-dependent solubility, and narrow absorption window. The purpose of this research was to prepare a floating-drug delivery-system of carvedilol to increase its half-life. The present study investigates the preparation of carvedilol-floating microspheres, evaluates the floating-drug delivery-system (FDDS) (by scanning electro...

Objective(s): The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an adjunct in acute pulmonary edema. The comparatively poor and inconstant B...

The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. Various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

Nano-boron, as a potential high-energy additive due to its high calorific value, is widely studied in propellants, explosives, and thermites. However, the unexpected agglomeration of surface oxidation hinders further application, especially casting energetic materials. The fluorine-modified nano-boron nB@F2603 nB@F2603@CL-20 preagglomerated microspheres were prepared by electrospray improve ign...

Carbon-coated Si/carbon nanotube/graphene oxide (C-Si/CNT/GO) microspheres with a robust core–shell composite structure were successfully fabricated by efficient and scalable spray-drying chemical vapor deposition (CVD) for application as lithium-ion battery (LIB) anode. The amphiphilic GO nanoparticles facilitated the uniform dispersion of Si suppressing CNT aggregation in Si/CNT/GO microspher...

One small-scale double emulsion technique for incorporation of Naja- Naja oxiana venom into Poly (lactide-co-glycolide) (PLGA) microspheres were developed and optimized. The effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and In vitro release of venom were studied. A stable double emulsion was verified by homogenization method. Slow...

In the long-term management of ulcerative colitis patients, repeat dosing maybe required. Since 5-ASA is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-ASA deliver...