Docetaxel (DTX) is one of the most important anticancer drugs; however, the severity of its adverse effects detracts from its practical use in the clinic. Magnetic nanoparticles of Fe3O4 (MgNPs-Fe3O4) can enhance the delivery and efficacy of anticancer drugs. We investigated the effects of MgNPs-Fe3O4 or DTX alone, and in combination with prostate cancer cell growth in vitro, as well as with th...

Antibacterial activity of Fe3O4 nanoparticles was investigated in three microorganisms including P. aeruginosa, E. Coli and Staphylococcus aureus. Fe3O4 nanoparticles were synthesized by chemical precipitation method (20 nm). The Fe3O4 nanoparticles antibacterial effect against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus were studied by the culture method. First of all, e...

in this work firstly fe3o4 nanoparticles were synthesized via a sono-chemical method. at the second step magnesium hydroxide shell was synthesized on the magnetite-core under ultrasonic waves. for preparation fe3o4-mgo the product was calcinated at 400 ºc for 2h. properties of the product were examined by x-ray diffraction pattern (xrd), scanning electron microscope (sem) and fourier transform ...

We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

OBJECTIVE Nanoparticles are becoming an important method of targeted drug delivery. To evaluate the importance of folate-conjugated human serum albumin (HSA) magnetic nanoparticles (Folate-CDDP/HSA MNP), we prepared drug-loaded Folate-CDDP/HSA MNPs and characterized their features. METHODS First, folate was conjugated with HSA under the effect of a condensing agent, and the conjugating rate w...

biomedical applications of superparamagnetic iron oxide nanoparticles (spions) requiring precise control over their physical and magnetic properties, and proper surface treatment. here we report a practical and effective electrochemical strategy for preparation of the polymer coated spions. in this strategy, in situ polymer coating on the surface of spions was achieved through electrodeposition...

In this work, Fe3O4@SiO2 core-shell nanocomposites were successfully synthesised via a simple co-precipitation method. X-ray diffraction pattern of clearly shows the existence main phase Fe3O4, beside an amorphous structure SiO2. The with average particle size in range 10-20 nm is observed by SEM and TEM images. FTIR spectrum illustrates Fe-O Si-O-Si bonds sample, indicating formed nanocomposit...

The application of Fe3O4 nanoparticles (NPs) has made great progress in the diagnosis of disease and in the drug delivery system for cancer therapy, but the relative mechanisms of potential toxicity induced by Fe3O4 have not kept pace with its development in the application, which has hampered its further clinical application. In this article, we used two kinds of human hepatoma cell lines, SK-...

Carboxylated SiO2-coated α-Fe nanoparticles have been successfully prepared via CaH2-mediated reduction of SiO2-coated Fe3O4 nanoparticles followed by surface carboxylation. These α-Fe-based nanoparticles, which are characterized by ease of coating with additional functional groups, a large magnetization of 154 emu per g-Fe, enhanced corrosion resistivity, excellent aqueous dispersibility, and ...

We report enhancement of the dielectric permittivity of poly(vinylidene fluoride) (PVDF) generated by depositing magnetic iron oxide (Fe3O4) nanoparticles on the surface of barium titanate (BT) to fabricate BT-Fe3O4/PVDF composites. This process introduced an external magnetic field and the influences of external magnetic field on dielectric properties of composites were investigated systematic...