Adipose tissue, stimulated by epinephrine (1, 2) or other hormones (3-6), discharges fatty acids into an incubation medium. It also can take up acids and esterify them (7). The possibility thus arises that the opposing effects, uptake and lipolysis, might be the forward and reverse aspects of a single process (8, 9). I f this is the case, the quantity of fatty acids taken up and the quantity re...

OBJECTIVE To determine whether autologously transferred human adipose tissue maintains viability in vivo for prolonged periods. DESIGN Six healthy female patients (mean age, 61.5 years; mean body mass index, 23.4 kg/m2) received autologous fat transplants from the gluteus to the nasolabial folds. Subcutaneous fat was sampled from facial and gluteal sites 4 times in 1 year. SETTING Private p...

BACKGROUND Marine n-3 polyunsaturated fatty acids may reduce coronary mortality. Previous data in relation to nonfatal coronary disease, however, have been inconsistent, which may be explained by the use of heterogeneous methods to assess the intake of marine n-3 polyunsaturated fatty acids. We investigated the hypothesis that the content of total and individual marine n-3 polyunsaturated fatty...

The seasonal changes in thermal physiology and torpor expression of many heterothermic mammals are controlled by photoperiod. As function at low body temperatures during torpor requires changes of tissue lipid composition, we tested for the first time whether and how fatty acids are affected by photoperiod acclimation in hamsters, Phodopus sungorus, a strongly photoperiodic species. We also exa...

BACKGROUND Chronic kidney disease (CKD) results in hypertriglyceridemia which is largely due to impaired clearance of triglyceride-rich lipoproteins occasioned by downregulation of lipoprotein lipase and very low-density lipoprotein (LDL) receptor in the skeletal muscle and adipose tissue and of hepatic lipase and LDL receptor-related protein in the liver. However, data on the effect of CKD on ...

1. Methods are described for the extraction and assay of acetyl-CoA and of total acid-soluble and total acid-insoluble CoA derivatives in rat epididymal adipose tissue. 2. The concentration ranges of the CoA derivatives in fat pads incubated in vitro under various conditions were: total acid-soluble CoA, 0.20-0.59mm; total acid-insoluble CoA, 0.08-0.23mm; acetyl-CoA, 0.03-0.14mm. 3. An investig...

The periparturient period of the lactation cycle in dairy cattle is characterized by dramatic changes in nutrient demand that necessitate exquisite coordination of metabolism to meet requirements for energy, glucose, and amino acids by the mammary gland following calving. To meet their energy requirements during the first weeks of lactation, dairy cows mobilize large quantities of fatty acids f...

background: with the increasing concern for health and nutrition, dietary fat has attracted considerable attention. the composition of fatty acids in the diet is important because they are associated with major diseases including cancers, diabetes, and cardiovascular disease. the fatty acid synthase (fasn) and stearoyl-coa desaturase (delta-9-desaturase) (scd) genes affect fatty acid compositio...

Obese adipose tissue is markedly infiltrated by macrophages, suggesting that they may participate in the inflammatory pathways that are activated in obese adipose tissue. Evidence has suggested that saturated fatty acids released via adipocyte lipolysis serve as a naturally occurring ligand that stimulates Toll-like receptor (TLR)4 signaling, thereby inducing the inflammatory responses in macro...

It is well established that insulin affects a number of processes involved in mammalian lipid metabolism. It stimulates the synthesis of fatty acids de now (lipogenesis) in liver, adipose tissue (white and brown), intestine and lactating mammary gland. The activity of lipoprotein lipase (EC 3.1.1.34) in white adipose tissue is increased by the hormone and therefore the uptake and re-esterificat...