A 64-year-old woman was admitted to hospital due to protracted diarrhea and liver dysfunction. The patient was diagnosed as Churg-Strauss syndrome (CSS) due to asthma, paranasal sinusitis, hypereosinophilia, and polyneuropathy. There was a history of taking montelukast, a leukotriene receptor antagonist (LTRA), which is thought to have some relationship with CSS. The liver biopsy specimen showe...

PURPOSE Nonalcoholic fatty liver disease (NAFLD) is a feature of metabolic syndrome and has a high prevalence in the general population. OBJECTIVE To determine the severity of atherosclerotic finding in various grade of NAFLD. MATERIAL AND METHODS We examined 250 consecutive patients with various grade of NAFLD and 85 control subjects matched for age, gender, to determine carotid intima-med...

Aortic valve stenosis (AVS), a valvulopathy that threatens life quality and longevity, in particular an aging population. Yet no medical treatment is to date available emphasizing the need for more mechanistic insight into disease provide future targets. Obesity genetic variants within genes involved lipid metabolisms lipoprotein (a) have emerged as risk factors AVS these significant genome-wid...

It has been reported in a previous paper (Dianzani, 1954) that uncoupling of oxidative phosphorylation occurs in fatty livers. Adenosine triphosphatase (ATPase) activity of mitochondria isolated from fatty livers is increased. Conversely, many substances which inhibit oxidative phosphorylation produce fatty infiltration of the liver when administered intraperitoneally to rats or mice (Dianzani ...