BACKGROUND In contrast to the conventional model of hospital-treated and government directly observed treatment (DOT) for multidrug-resistant tuberculosis (MDR-TB) patient care, the Taiwan MDR-TB Consortium (TMTC) was launched in May 2007 with the collaboration of five medical care groups that have provided both care and DOT. This study aimed to determine whether the TMTC provided a better care...

Bevacizumab (BZM) and temozolomide (TMZ) have been shown to be beneficial in the treatment of patients with glioblastoma. We sought evidence for the benefit of BZM in the general patient population at large. The Surveillance, Epidemiology, and End Results SEER database was queried for patients diagnosed with glioblastoma between 2000 and 2009, divided into a pre-TMZ era (January 2000-June 2003)...

OBJECTIVE To examine the frequency and phenotype of Th17 cells in the peripheral blood of early RA (eRA) patients. METHODS CD4+ T cells were isolated from the peripheral blood of 33 eRA patients, 20 established RA patients and 53 healthy controls (HC), and from the synovial fluid of 20 established RA patients (RASF), by ficoll-hypaque gradient and magnetical negative selection. After polyclon...

bioinformatics in the post genomic era genome bioinformatics in the post genomic era genome bioinformatics in the post genomic era genome free download bioinformatics in the post-genomic era bioinformatics in the post genomic era genome bioinformatics on post genomic era: from genomes to bioinformatics in the post genomic era genome bioinformatics for cancer management in the post-genome era bi...

iran is a society with religious infrastructure, in which islam and shiism have had great influence. meanwhile culture and iranian literature, especially poetry has a great position in reflecting religious symbols. ghajarid era is one of the persian literature periods in which religion, especially shiism has great reflection. in this era, by reinforcing religious bases of poems, poets try to tr...

This paper gives the history of verification and validation of discrete-event simulation models as seen through the eyes of its authors and their experiences. The history is divided into three time periods: the early era covering years up to 1970, the awareness era covering the years of the 1970s and 1980s, and the modern era covering the years of 1990 to the present.

AIM To examine whether high-flow nasal oxygen (HFNO) availability influences the use of general anesthesia (GA) in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and associated outcomes. METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for de...

Background Cure rates for chronic hepatitis C have improved dramatically with direct-acting antivirals (DAAs), but treatment barriers remain. We aimed to compare treatment initiation rates and barriers across both interferon-based and DAA-based eras. Methods We conducted a retrospective cohort study of all patients with chronic hepatitis C seen at an academic hepatology clinic from 1999 to 20...

BACKGROUND Identification of parameters for early diagnosis and treatment response would be beneficial for patients with early rheumatoid arthritis (ERA) to prevent ongoing joint damage. miRNAs have features of potential biomarkers, and an altered expression of miRNAs was shown in established rheumatoid arthritis (RA). OBJECTIVE To analyse RA associated miRNAs in the sera of patients with ERA...