Wilson disease is an autosomal recessive disorder characterized by the progressive accumulation of copper in the body. The failure of hepatocytes to excrete copper into bile and the decreased copper incorporation into ceruloplasmin causes the metal to accumulate in the body (1-5). In 1993, Wilson disease gene, ATP7B, was identified by separate groups (6-8). ATP7B encodes a metal-transporting P-...

BACKGROUND Hanging is the most frequently used method of suicide in the UK and has high case fatality (>70%). AIMS To explore factors influencing the decision to use hanging. METHOD Semi-structured qualitative interviews with 12 men and 10 women who had survived a near-fatal suicide attempt. Eight respondents had attempted hanging. Data were analysed thematically and with constant compariso...

BACKGROUND Several suicide and suicidal behaviour risk factors are highly prevalent in asylum seekers, but there is little insight into the suicide death rate and the suicidal behaviour incidence in this population. The main objective of this study is to assess the burden of suicide and hospital-treated non-fatal suicidal behaviour in asylum seekers in the Netherlands and to identify factors th...

OBJECTIVE Suicide attempts (SAs) in the paediatric age group represent an important cause of morbidity and mortality. Our aim was to examine the factors affecting the decision to hospitalize children with a diagnosis of non-fatal SA by pills. METHODS Children <18 years of age admitted with SA by pills during 2014 were evaluated retrospectively. Patients were divided into two groups: Group-I c...

The aims of this study were to describe fatal and non-fatal self-harm burdens, as well as burdens from the main preventable risk factors, and to investigate the different suicide methods in Hubei province in central China utilizing data from both Global Burden of Disease Study 2015 and Hubei Disease Surveillance Points system. All self-harm burdens including mortality, years of life lost (YLLs)...

Death by suicide occurs in a disproportionate percentage of individuals with anorexia nervosa (AN), with a standardized mortality ratio indicating a 57-fold greater risk of death from suicide relative to an age-matched cohort. Longitudinal studies indicate impaired social functioning increases risk for fatal outcomes, while social impairment persists following recovery. Study of social cognitio...

Affecting approximately eight million people in the US, bipolar disorder represents a significant public health concern. Over 90% of individuals diagnosed with the disorder report multiple affective episodes across their lifetime, and recent data suggest that patients with bipolar disorder will remain symptomatically ill for roughly 50% of their lives. Consistent with this chronic course, bipol...

This brief review summarizes the basic epidemiology of firearm violence, a large and costly public health problem in the United States for which the mortality rate has remained unchanged for more than a decade. It presents findings for the present in light of recent trends. Risk for firearm violence varies substantially across demographic subsets of the population and between states in patterns...

BACKGROUND An important gender difference has been reported regarding suicidal behavior with an overrepresentation of females in nonfatal suicidal behavior and a preponderance of males in completed suicide, also known as the 'gender paradox of suicidal behavior'. The concept of a 'suicidal process' classifies suicidal behavior chronologically; this process starts with suicidal ideation and then...