A 58-year-old gentleman presented with gradually progressive left hand weakness for one year. Left leg dragging and dysarthria developed 3months before visiting our neurology clinics. Neurological examination revealed muscle atrophy without fasciculation in the left first dorsal interosseous and triceps brachii muscles. Left spastic hemiparesis with exaggerated jaw jerk and flaccid dysarthria w...

Case presentation: J.A.R, 2 years old, only child of a couple with no history neurological diseases, born at term, pregnancy and delivery without complications, normal development in the first trimester life. At 4 months, delayed neuromotor was noticed, cephalic support, did not follow objects or search for faces, presented tongue fasciculation, hypotonia hyporeflexia. 5 months he had strabismu...

The accuracy of axonal pathfinding and the formation of functional neural circuitry are crucial for an organism to process, store, and retrieve information from internal networks as well as from the environment. Aberrations in axonal migration is believed to lead to loop formation and self-fasciculation, which can lead to highly dysfunctional neural circuitry and therefore self-avoidance of axo...

A case of interstitial myositis associated with a localised lipoatrophy is reported. The patient is a 24 year old man who presented with severe painful cramps and fasciculations localised to one limb. The rarity of both disorders, and their likely common autoimmune mechanism, suggest that this is not a chance association.

Glia-axon interactions are essential for the development and function of the nervous system. We combine in vivo imaging and genetics to address the mechanism by which the migration of these cells is coordinated during embryonic development. Using stable transgenic lines, we have followed the migration of one subset of glial cells and their target axons in living zebrafish embryos. These cells c...

In gnathostome vertebrates, including fish, birds and mammals, peripheral nerves link nervous system, body and immediate environment by integrating efferent pathways controlling movement apparatus or organ function and afferent pathways underlying somatosensation. Several lines of evidence suggest that peripheral nerve assembly involves instructive interactions between efferent and afferent axo...

Review was made of the symptoms, treatment and outcome of 151 cases of severe envenomation by the scorpion Centruroides sculpturatus treated with antivenom, 1988-1989. The most frequent symptoms were restlessness, nystagmus, paresthesiae, hypersalivation, fasciculation, blurred vision and dysphagia with an average of four symptoms. Medications before antivenom, given to about half of the subjec...

We report four Brazilian siblings with Autosomal Dominant Hereditary Motor Sensory Neuropathy with Proximal Dominant Involvement (HMSN-P), a rare form of HMSN, that was characterized by proximal dominant muscle weakness and atrophy onset after the age of 30 years, fasciculation, arreflexia and sensory disturbances with autosomal dominant inheritance. Electrophysiological study and sural nerve b...

Lithium salts have been used in treatment of depression and bipolar disorder for more than 50 years. Neurotoxic side-effects such as nystagmus, ataxia, tremor, fasciculation, clonus, seizure and even coma have been well described in the literature. We present a case of generalised peripheral neuropathy following lithium intoxication. It is a rare presentation with delayed onset and characterise...

Muscle ultrasound is a useful tool of the neuromuscular disease. On muscle ultrasound, we can detect the affected muscle as increase of muscle echo intensity because of the fibrosis and fatty infiltration. Muscle atrophy and thickened muscle fascia are also visualized with muscle ultrasound. Another advantage of muscle ultrasound compared to other imaging technique is to visualize muscle moveme...