Terpenes are the most abundant class of natural product that exist in nature. They possess a myriad industrial applications including pharmaceutical, perfumery and flavors, bulk chemicals, fuel. Intriguingly, until today, vast majority characterized terpenoids have been isolated from plants fungi, only recent years bacteria were found to generate representative reservoir molecules. Mining Strep...

Natural sesquiterpene synthases have evolved to make complex terpenoids by quenching reactive carbocations either proton transfer or hydroxylation (water capture), depending on their active site. Germacradien-11-ol synthase (Gd11olS) from Streptomyces coelicolor catalyzes the cyclization of farnesyl diphosphate (FDP) into hydroxylated germacradien-11-ol. Here, we combine experiment and simulati...

We screened 26 bisphosphonates against a farnesyl diphosphate synthase from Plasmodium vivax, finding a poor correlation between enzyme and cell growth inhibition (R(2) = 0.06). To better predict cell activity data, we then used a combinatorial descriptor search in which pIC(50)(cell) = a pIC(50)(enzyme) + bB + cC + d, where B and C are descriptors (such as SlogP), and a-d are coefficients. R(2...

the genus hypericum is one of the most important medicinal plants that contain 17 species in iran, three of them are endemics. this paper reports the essential oil composition of eight hypericum species from iran. the essential oil analysis of a number of the studied plants has already been reported but their report from iran may be valuable for scientists.  samples collected from different pla...

A high yield cellulase production strain was screened from the surface of cigar wrapper leaves and added to for fermentation in present study. The enzyme-producing identified as Bacillus velezensis, its maximum carboxymethyl activity could reach 44.3 U/mL. Making cellulose degradation rate index, temperature, inoculum concentration, carbon nitrogen source addition concentration were optimized b...