From the *Laboratory ofImmunochemistry and the 1Division of Tumor Virology, Dana-Farber Cancer Institute; the SDepartment of Rheumatology and Immunology, Harvard Medical School, Boston, Massachusetts, 02115; the uDepartment of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138, and the (Division of Rheumatology, Children's Hospital Medical Center, Cincinnati,...

Rinath M Jeselsohn, William T Barry, Jin Zhao, Gilles Buchwalter, Cristina Guarducci, Ilenia Migliaccio, Chiara Biagioni, Martina Bonechi, Naomi Laing, Yuri Rukazenkov, Eric P Winer, Myles Brown, Angelo Di Leo and Luca Malorni. Dana-Farber Cancer Institute, Boston, MA; Hospital of Prato, Istituto Toscano Tumori, Prato, Italy; "Sandro Pitigliani" Medical Oncology Unit, IstitutoToscano Tumori, Pr...

1Hematology/Oncology, Children’s Hospital Boston, MA; 2Harvard Medical School, Boston, MA; 3Dana-Farber Cancer Institute, Boston, MA; 4Clinical Pharmacology Unit, Children’s Hospital Boston, MA; 5Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, ON; 6Division of Nuclear Medicine, Children’s Hospital Boston, MA; and 7Novartis Pharmaceut...

LIVING HISTORY One of the monumental discoveries in medicine during the last century was that recorded by Farber et al. in 1948. The team at the Boston Children’s Hospital found that a simple compound administered systemically to children with leukemia caused a remission of the thitherto universally lethal disease. Members of that research team who were then Fellows were asked recently to recor...

Steven and Alexandra Cohen Children’s Medical Center of New York, New Hyde Park, NY; Feinstein Institute for Medical Research, Manhasset, NY; University of Arkansas for Medical Sciences, Little Rock, AR; Dana-Farber Cancer Institute, Boston, MA; Harvard Medical School, Boston, MA; Department of Hematology, Brigham and Women’s Hospital, Boston, MA; Office of the Clinical Director, National Human...

Analysis of lipid storage in postmortem brains of patients with amaurotic idiocy led to the recognition of five lysosomal ganglioside storage diseases and identification of their inherited metabolic blocks. Purification of lysosomal acid sphingomyelinase and ceramidase and analysis of their gene structures were the prerequisites for the clarification of Niemann-Pick and Farber disease. For lipi...

Donald Tindall, Frances McFarland Horne, Andrew Hruszkewycz, Suresh Mohla, Marc Shuman, Zhou Wang, and Philip Kantoff 6 Mayo Clinic, Rochester, Minnesota; Palladian Partners, Inc., Silver Spring, Maryland; National Cancer Institute, Bethesda, Maryland; University of California San Francisco, San Francisco, California; Northwestern University, Chicago, Illinois; and Dana-Farber Cancer Institute,...

Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24060, USA Center for Complex Network Research, Departments of Physics, Biology, and Computer Science, Northeastern University, Boston, MA 02115, USA. Department of Medicine, Harvard Medical School, and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. National Heart, Lung and Blood Institutes...

From the * Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; the ‡ Dana Farber Cancer Institute, Boston, Massachusetts 02115; § The Rockefeller University, New York 10021; the i Laboratory of Clinical Investigation and the ¶ Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryla...

Correspondence to: Marc S. Halfon; Department of Biochemistry; Center of Excellence in Bioinformatics; State University of New York at Buffalo; 140 Farber Hall, 3435 Main Street; Buffalo, New York 14214-3000 USA; Tel.: 716.829.8126; Fax: 716.829.2725; Email: [email protected]/ David N. Arnosti; Department of Biochemistry and Molecular Biology; Michigan State University; East Lansing, Michiga...