نتایج جستجو برای: farahzads cda model

تعداد نتایج: 2106251  

Journal: :Biochemistry 2011
Richard S Hall Alexander A Fedorov Chengfu Xu Elena V Fedorov Steven C Almo Frank M Raushel

Cytosine deaminase (CDA) from E. coli is a member of the amidohydrolase superfamily. The structure of the zinc-activated enzyme was determined in the presence of phosphonocytosine, a mimic of the tetrahedral reaction intermediate. This compound inhibits the deamination of cytosine with a K(i) of 52 nM. The zinc- and iron-containing enzymes were characterized to determine the effect of the dival...

Journal: :Haematologica 1999
F Lauria M Bocchia G Marotta D Raspadori P L Zinzani D Rondelli

BACKGROUND AND OBJECTIVE It has been widely demonstrated that one single 7-day course continuous infusion (c.i.) 2-chlorodeoxyadenosine (2-CdA) at a dose of 0.1 mg/kg daily is dramatically effective in inducing high and prolonged complete remission (CR) rates in patients with hairy-cell leukemia (HCL). However, 2-CdA administration often results in severe neutropenia and lymphocytopenia both re...

2010
Roberta Russo Maria Rosaria Esposito Roberta Asci Antonella Gambale Silverio Perrotta Ugo Ramenghi Gian Luca Forni Vedat Uygun Jean Delaunay Achille Iolascon

SEC23B gene encodes an essential component of the coat protein complex II (COPII)-coated vesicles. Mutations in this gene cause the vast majority the congenital dyserythropoietic anemia Type II (CDA II), a rare disorder resulting from impaired erythropoiesis. Here, we investigated 28 CDA II patients from 21 unrelated families enrolled in the CDA II International Registry. Overall, we found 19 n...

Journal: :Blood 1996
M S Tallman D Hakimian A W Rademaker C Zanzig E Wollins E Rose L C Peterson

Although 2-chlorodeoxyadenosine (2-CdA) is effective in inducing complete remissions (CRs) in the majority of patients with hairy cell leukemia (HCL), neither the actual relapse rate, the clinical factors that may predict relapse, the long-term outcome, nor the response rate to re-treatment at relapse has been clearly determined. Fifty-two consecutive patients with previously untreated or treat...

Journal: :IJICTE 2008
Dick Ng'ambi

It is difficult to understand students’ social practices from artifacts of anonymous online postings. The analysis of text genres and discursive types of online postings has potential for enhancing teaching and learning experiences of students. This article focuses on analysis of students’ anonymous online postings using Critical Discourse Analysis (CDA). The article argues that social practice...

2015
Xiaolong Tang Jingjing Dai Jun Xie Yongqiang Zhu Ming Zhu Zhi Wang Chunmei Xie Aixia Yao Tingting Liu Xiaoyu Wang Li Chen Qinglin Jiang Shulei Wang Yong Liang Congjing Xu

Fungal infections are an important cause of morbidity and mortality in immunocompromised patients. Amphotericin B (AMB), with broad-spectrum antifungal activity, has long been recognized as a powerful fungicidal drug, but its clinical toxicities mainly nephrotoxicity and poor solubility limit its wide application in clinical practice. The fungal metabolism along with the host immune response us...

Journal: :World journal of gastroenterology 2011
Greetje J Tack Wieke H M Verbeek Abdul Al-Toma Dirk J Kuik Marco W J Schreurs Otto Visser Chris J J Mulder

AIM To evaluate cladribine [2-chlorodeoxyadenosine (2-CdA)] therapy in refractory celiac disease (RCD) II. METHODS An open-label cohort-study of RCD II patients treated with 2-CdA was performed between 2000 and 2010. Survival rate, enteropathy associated T-cell lymphoma (EATL) occurrence, clinical course, and histological and immunological response rates were evaluated. RESULTS Overall, 32 ...

Journal: :Pacific Journal of Mathematics 2004

Journal: :Studies in health technology and informatics 2014
Catherine E. Chronaki Ana Estelrich Giorgio Cangioli Marcello Melgara Dipak Kalra Zabrina Gonzaga Larry Garber Elaine Blechman Jamie Ferguson Stephen Kay

In an increasingly mobile world, many citizens and professionals are frequent travellers. Access during unplanned care to their patient summary, their most essential health information in a form physicians in another country can understand can impact not only their safety, but also the quality and effectiveness of care. International health information technology (HIT) standards such as HL7 CDA...

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